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Por favor, use este identificador para citar o enlazar este ítem: http://uvadoc.uva.es/handle/10324/21766
Título: Mineralization and bone regeneration using a bioactive elastin-like recombinamer membrane
Autor: Klymov, Alexey
Reza Nejadnik, M.
Alonso Rodrigo, Matilde
Rodríguez Cabello, José Carlos
Walboomers, X. Frank
Mata, Álvaro
Año del Documento: 2014
Descripción: Producción Científica
Documento Fuente: Biomaterials, 2014, Septiembre, vol. 35 n. 29 p. 8339-47
Resumen: In the field of tissue engineering, the properties of the scaffolds are of crucial importance for the success of the application. Hybrid materials combine properties of the different components that constitute them. In this study hybrid gels of elastin-like recombinamer (ELR) and fibrin were prepared with a range on polymer concentrations and ELR-to-fibrin ratios. The correlation between SEM micrographs, porosity, swelling ratio and rheological properties was discussed and a poroelastic mechanism was suggested to explain the mechanical behavior of the hybrid gels. Applicability as scaffold material for cardiovascular tissue engineering was shown by the realization of cell-laden matrixes which supported the synthesis of collagens as revealed by immunohistochemical analysis. As a proof of concept, a tissue-engineered heart valve was fabricated by injection moulding and cultivated in a bioreactor for 3 weeks under dynamic conditions. Tissue analysis revealed production of collagen I and III, fundamental proteins for cardiovascular constructs.
Materias (normalizadas): Ingeniería Química
ISSN: 0142-9612
Revisión por Pares: SI
DOI: 10.1016/j.biomaterials.2014.05.095.
Patrocinador: Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13)
Idioma: spa
URI: http://uvadoc.uva.es/handle/10324/21766
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:DEP60 - Artículos de revista

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