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Por favor, use este identificador para citar o enlazar este ítem: http://uvadoc.uva.es/handle/10324/21773
Título: Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes
Autor: González de Torre, Israel
Quintanilla, Luis
Pinedo Martín, Guillermo
Rodríguez Cabello, José Carlos
Alonso Rodrigo, Matilde
Año del Documento: 2014
Editorial: American Chemical Society
Descripción: Producción Científica
Documento Fuente: ACS Applied Materials and Interfaces. July 2014, vol 6 n. 16. p. 14509-14515
Resumen: Diluted, complementary, click-reactive elastin-like recombinamer (ELR) solutions have been prepared and mixed at two different temperatures, one below and one above the characteristic transition temperature (Tt) of these chemically modified ELRs. FTIR measurements, size, aspect ratio, zeta potential, and microrheological measurements have been carried out on the nanostructures formed under these dilute conditions as a way to better understand the relationship between the final macroscopic properties of ELR-based hydrogels and the molecular conditions governing the initial stages of the chemical cross- linking process that occurs, especially its dependence on the preparation temperature relative to Tt. As a result, two different fractal modes of gel formation have been found at the two temperatures studied (above and below Tt). Thus, when the reaction mixture is prepared below Tt, essentially one-dimensional linear nanogels with a high aspect ratio are obtained. In contrast, 3D nanogels are formed above Tt, with spherical shapes predominating. These different structures seem to reflect the two molecular organizations of the single components of the mixture under these conditions, namely extended chains below Tt and a spherical arrangement above Tt. In addition to the interest in these nanogels as models for understanding the formation of microscopic structures and differential macroscopic properties under more conventional hydrogel-formation conditions, these nanogels are of interest because of their thermoresponsiveness and biocompatibility, which provide them with potential uses for drug delivery and other biomedical applications in living systems.
Materias (normalizadas): Nanogeles
ISSN: 1944-8244
Revisión por Pares: SI
DOI: 10.1021/am503651y
Patrocinador: Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13)
Version del Editor: http://pubs.acs.org/journal/aamick
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/21773
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:DEP60 - Artículos de revista

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