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Title: Non-steroidal anti-inflammatory drugs (NSAIDs) and neuroprotection in the elderly: a view from the mitochondria
Authors: Calvo Rodríguez, María
Villalobos, Carlos
Nuñez Llorente, Lucía
Issue Date: 2015
Publisher: Medknow Publications
Description: Producción Científica
Citation: Neural Regen Res 10 (9), 1371-1372.
Abstract: The most important risk factor for stroke and neurodegeneration is aging. In fact, survival after stroke diminishes largely with aging. In fact, recovery after brain artery occlusion is dramatically worsened by aging, even normal aging is associated with neuron damage and cognitive decline. Mechanisms involved in aging-related, cognitive decline and susceptibility to neuron damage in stroke and neurodegeneration are largely unknown. One of the most important mechanisms contributing to neural dysfunction and death is excitotoxicity. This process is based on the fact that the excessive glutamate receptor stimulation may lead to neuronal damage. This overstimulation may be due to increased concentration of glutamate, or the prolonged activation of receptors.
Keywords: Mitochondria
ISSN: 1673-5374
Peer Review: SI
DOI: 10.4103/1673-5374.165219
Sponsor: Ministerio de Economía y Competitividad (BFU2012- 37146)
Junta de Castilla y León (VA145U13, BIO/VA33/13, BIO103/VA45/11)
Publisher Version:
Language: eng
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:DEP06 - Artículos de revista

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