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Title: Clinical, Refractive and Histological Reversibility of Corneal Additive Surgery in Deep Stroma in an Animal Model.
Authors: Ibares-Frías, Lucía
Gallego, Patricia
Cantalapiedra-Rodriguez, Roberto
Merayo-Lloves, Jesús
Martínez-García, María Carmen
Issue Date: 2016
Publisher: Taylor & Francis
Description: Producción Científica
Citation: Current eye Research ,(2016); 41(9):1192-1201
Abstract: The aim was to evaluate the reversibility of the clinical and histological changes induced in the corneas of an animal model after removing an intracorneal ring segment (ICRS).Surgery for this study was performed in 38 eyes of an experimental animal model (Gallus domesticus) for ICRS surgery (Ferrara technique). The animals without complications were randomized to two groups; in all of them, 1 segment was implanted in each eye and later removed at different times (1 and 3 months after implantation). In each group, after explantation, corneas were processed at different times for histological analysis with hematoxylin and eosin (H&E) stain and electronic microscopy. The refractive state of the eyes was also measured.In corneas without complications (88.23%), explantation was performed correctly. During the first few days, around the area where the ICRS was implanted we observed deposits of cells and a moderate degree of corneal opacity (haze). These signs decreased progressively without disappearing completely. Histologically, at 7 days, we observed hyperplasia and abnormal arrangement of collagen fibers. Later, these findings also decreased in both groups, albeit at a faster rate in group 1. Minimal changes were observed in electron microscopy up to the end of the study in both groups. Preoperative refractive state was achieved at 1 month after explantation in both groups.ICRS can safely be explanted from the cornea. Refractive reversibility was achieved at 1 month after explantation. However, the clinical and histological findings after ICRS explantation depend on the time from implantation to explantation.
Keywords: Córnea - Cirugía
ISSN: 0271-3683
Peer Review: SI
DOI: 10.3109/02713683.2015.1114652
Language: eng
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:DEP05 - Artículos de revista

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