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Title: Spirolactone iridoids might be responsible for the antileishmanial activity of a Peruvian traditional remedy made with Himatanthus sucuuba (Apocynaceae)
Authors: Castillo, D.
Arevalo, J.
Herrera, F.
Ruiz, C.
Rojas, R.
Rojas, R.
Vaisberg, A.
Lockb, O.
Lemesre, J.-L.
Gornitzka, H.
Sauvain, M.
Issue Date: 2007
Publisher: Elsevier
Description: Producción Científica
Citation: J Ethnopharmacol, (2007);112(2):410-4
Abstract: Extracts of seven medicinal plants used specifically against cutaneous leishmaniasis in the Madre de Dios region of Peru were evaluated in vitro against promastigote and axenic amastigote forms of Leishmania amazonensis. One of them showed interesting leishmanicidal activities (IC50 =5!g/ml in amastigotes). Bio-guided isolation of the stem bark’s ethanol extract of Himatanthus sucuuba (Spruce ex M¨ull. Arg.) Woodson (Apocynaceae) afforded the spirolactone iridoids isoplumericin and plumericin. The latter showed a reduction of macrophage infection similar to that of the reference drug Amphotericin B (IC50 = 0.9 and 1!M, respectively). These findings validate the traditional use of Himatanthus sucuuba in the treatment of cutaneous leishmaniasis (Uta) in Peru.
Keywords: Leishmaniasis - Tratamiento
ISSN: 0378-8741
Peer Review: SI
DOI: 10.1016/j.jep.2007.03.025
Language: eng
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:DEP05 - Artículos de revista

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