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dc.contributor.author | Escudero Hernández, Celia | |
dc.date.accessioned | 2017-03-15T08:38:41Z | |
dc.date.available | 2017-03-15T08:38:41Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Innate Immunity, 2017 Vol. 23(1), pp. 44-53 | es |
dc.identifier.issn | 1753-4259 | es |
dc.identifier.uri | http://uvadoc.uva.es/handle/10324/22616 | |
dc.description | Producción Científica | es |
dc.description.abstract | IL-15 is a pleiotropic cytokine related to IL-2 which acts at a broader level than its counterpart. It is presented through its specific high-affinity receptor, IL-15Ra. Both cytokine and receptor are tightly regulated at multiple levels and are widely distributed. Thus, deregulation of their expression leads to an inflammatory immune response. Variants of splicing of IL-15Ra have been described in immune and barrier cells; however, their presence has not been focused on intestinal epithelial cells. In this study, we describe five new alternative variants of splicing of IL-15Ra in Caco-2 cells. Four of them were expressed into proteins inside Caco-2 cells, but these were unable to bind IL-15 or to follow the secretory pathway. However, the expression of mRNA itself might be relevant to diseases such as celiac disease, inflammatory bowel disease or colorectal cancer. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | International Endotoxin and Innate Immunity Society | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.classification | Cáncer colorrectal | es |
dc.subject.classification | Enfermedad celíaca | es |
dc.subject.classification | Colon irritable | es |
dc.title | New IL-15 receptor-α splicing variants identified in intestinal epithelial Caco-2 cells | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1177/175342 5916674263 | es |
dc.relation.publisherversion | https://journals.sagepub.com/doi/10.1177/1753425916674263 | |
dc.identifier.publicationfirstpage | 1 | es |
dc.identifier.publicationlastpage | 10 | es |
dc.identifier.publicationtitle | Innate Immunity | es |
dc.identifier.publicationvolume | 2 | es |
dc.peerreviewed | SI | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
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