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Título: New IL-15 receptor-a splicing variants identified in intestinal epithelial Caco-2 cells
Autor: Escudero Hernández, Celia
Año del Documento: 2016
Editorial: Universidad de Valladolid. Facultad de Medicina
Descripción: Producción Científica
Documento Fuente: Innate Immunity, November 2016, vol.2
Resumen: IL-15 is a pleiotropic cytokine related to IL-2 which acts at a broader level than its counterpart. It is presented through its specific high-affinity receptor, IL-15Ra. Both cytokine and receptor are tightly regulated at multiple levels and are widely distributed. Thus, deregulation of their expression leads to an inflammatory immune response. Variants of splicing of IL-15Ra have been described in immune and barrier cells; however, their presence has not been focused on intestinal epithelial cells. In this study, we describe five new alternative variants of splicing of IL-15Ra in Caco-2 cells. Four of them were expressed into proteins inside Caco-2 cells, but these were unable to bind IL-15 or to follow the secretory pathway. However, the expression of mRNA itself might be relevant to diseases such as celiac disease, inflammatory bowel disease or colorectal cancer.
Palabras Clave: Cáncer colorectal
Enfermedad celíaca
Colon irritable
ISSN: 1753-4259
Revisión por Pares: SI
DOI: 10.1177/175342 5916674263
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/22616
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:DEP55 - Artículos de revista

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