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Title: New IL-15 receptor-a splicing variants identified in intestinal epithelial Caco-2 cells
Authors: Escudero Hernández, Celia
Issue Date: 2016
Publisher: Universidad de Valladolid. Facultad de Medicina
Description: Producción Científica
Citation: Innate Immunity, November 2016, vol.2
Abstract: IL-15 is a pleiotropic cytokine related to IL-2 which acts at a broader level than its counterpart. It is presented through its specific high-affinity receptor, IL-15Ra. Both cytokine and receptor are tightly regulated at multiple levels and are widely distributed. Thus, deregulation of their expression leads to an inflammatory immune response. Variants of splicing of IL-15Ra have been described in immune and barrier cells; however, their presence has not been focused on intestinal epithelial cells. In this study, we describe five new alternative variants of splicing of IL-15Ra in Caco-2 cells. Four of them were expressed into proteins inside Caco-2 cells, but these were unable to bind IL-15 or to follow the secretory pathway. However, the expression of mRNA itself might be relevant to diseases such as celiac disease, inflammatory bowel disease or colorectal cancer.
Classification: Cáncer colorectal
Enfermedad celíaca
Colon irritable
ISSN: 1753-4259
Peer Review: SI
DOI: 10.1177/175342 5916674263
Language: eng
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:DEP55 - Artículos de revista

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