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Título: Synthesis and Characterization of Amide Stationary Phases for the Determination of Sulfonamides by Sequential Injection Chromatography
Autor: Islas, Gabriela
Rodríguez, José Antonio
Cruz-Borbolla, Julián
Vásquez-Pérez, José M.
Barrado, Enrique
Año del Documento: 2016
Editorial: Taylor & Francis
Descripción: Producción Científica
Documento Fuente: Analytical Letters, 2016 Vol. 49 N. 5 p. 676-689
Resumen: The synthesis of amide (butyl, cyclohexyl, and phenyl) modified silica and the use as stationary phases in sequential injection chromatogra-phy are described. The system was tested on the isocratic separation of seven sulfonamides (sulfachloropyridazine, sulfadimethoxine, sulfame-thazine, sulfamethoxazole, sulfamethoxypyridazine, sulfaquinoxaline, and sulfathiazole) using each stationary phase with mobile phases composed of acetonitrile/water at a flow rate of 0.45 mL min−1. A mixed mode retention mechanism of sulfonamides in the stationary phases was obtained, including dipole-dipole, π-π, and hydrogen bonding interactions. The most appropriate phase for the separation of sulfonamides was phenylamide. The chromatographic behavior was confirmed using density functional theory of the interaction between sulfamethoxazole and the stationary phases.
Palabras Clave: Density functional theory; sequential injection chromatography; solid phase interaction; sulfonamides
ISSN: 0003-2719
Revisión por Pares: SI
DOI: 10.1080/00032719.2015.1045589
Patrocinador: Junta de Castilla y León Proyecto VA171U14
Propietario de los Derechos: Taylo & Francis
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/24230
Derechos: info:eu-repo/semantics/restrictedAccess
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