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Title: Chemotransduction in the Carotid Body: K+ Current Modulated by Po2 in Type 1Chemoreceptor Cells
Authors: López Barneo, J.
López López, José Ramón
Ureña, J.
González, Constancio
Issue Date: 1988
Publisher: American Association for the Advancement of Science
Description: Producción Científica
Citation: Science, vol. 241. p.580-582.
Abstract: The ionic currents of carotid body type 1cells and their possible involvement in the detection of oxygen tension (Po2) in arterial blood are unknown. The electrical properties of these cells were studied with the whole-cell patch clamp technique, and the hypothesis that ionic conductances can bealtered by changes in Po2 was tested. The results show that type 1cells have voltage-dependent sodium, calcium, and potassium channels. Sodium and calcium currents were unaffected by a decrease in Po2 from 150 to 10 millimeters of mercury, whereas, with the same experimental protocol, potassi­ um currents were reversibly reduced by 25 to 50 percent. The effect of hypoxia was independent of internal adenosine triphosphate and calcium. Thus, ionic conductances, and particularly the 02-sensitive potassium current, play a key role in the transduction mechanism of arterial chemoreceptors.
Classification: Cuerpo carotideo
ISSN: 0036-8075
Peer Review: SI
Language: spa
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:DEP06 - Artículos de revista

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