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Título: Elastin-like polypeptides in drug delivery
Autor: Rodríguez Cabello, José Carlos
Arias, Francisco Javier
Alonso Rodrigo, Matilde
Girotti, Alessandra
Año del Documento: 2016
Editorial: Elsevier
Descripción: Producción Científica
Documento Fuente: Advanced Drug Delivery Reviews Volume 97, 1 February 2016, Pages 85-100
Resumen: The use of recombinant elastin-like materials, or elastin-like recombinamers (ELRs), in drug-delivery applications is reviewed in this work. Although ELRs were initially used in similar ways to other, more conventional kinds of polymeric carriers, their unique properties soon gave rise to systems of unparalleled functionality and efficiency, with the stimuli responsiveness of ELRs and their ability to self-assemble readily allowing the creation of advanced systems. However, their recombinant nature is likely the most important factor that has driven the current breakthrough properties of ELR-based delivery systems. Recombinant technology allows an unprecedented degree of complexity in macromolecular design and synthesis. In addition, recombinant materials easily incorporate any functional domain present in natural proteins. Therefore, ELR-based delivery systems can exhibit complex interactions with both their drug load and the tissues and cells towards which this load is directed. Selected examples, ranging from highly functional nanocarriers to macrodepots, will be presented.
Revisión por Pares: SI
DOI: 10.1016/j.addr.2015.12.007
Patrocinador: info:eu-repo/grantAgreement/EC/H2020/642687
Patrocinador: Ministerio de Economía, Industria y Competitividad (Project PRI-PIBAR-2011-1403, MAT2012-38043, MAT2013-42473-R and MAT2013- 4 17 23-R)
Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. (VA152A12, VA155A12 and VA313U14)
Version del Editor: http://www.sciencedirect.com/science/article/pii/S0169409X15300016
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/24759
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Documentos OpenAire(Open Access Infrastructure for Research in Europe)
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