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Por favor, use este identificador para citar o enlazar este ítem: http://uvadoc.uva.es/handle/10324/25016
Título: Local Calcium Transients Triggered by Single L-Type Calcium Channel Currents in Cardiac Cells
Autor: López López, José Ramón
Shacklock, Philip S.
Balke, C. William
Gil, Withrowl
Año del Documento: 1995
Editorial: American Association for the Advancement of Science
Descripción: Producción Científica
Documento Fuente: Science, vol.268, n.5213 p.1042-1045
Resumen: Excitation-contraction coupling was studied in mammalian cardiac cells in which the opening probability of L-type calcium (Ca2 +) channels was reduced. Confocal microscopy during voltage-clamp depolarization revealed distinct local transients inthe concentration of intracellular calcium ions ([Ca2 +]¡). When voltage was varied, the latency to occurrence and the relative probability of occurrence of local [Ca2 +]; transients varied as predicted if ca2 + release from the sarcoplasmic reticulum (SR) was linked tightly to Ca2 + flux through L-type Ca2 + channels but not to that through the Na-Ca exchanger or to average [Ca2 +];. Voltage had no effect on the amplitude of local [Ca2 +]; transients. Thus, the most efficacious "Ca2 + signal" for activating Ca2 + release from the SR may be a transient microdomain of high [Ca2 +]; beneath an individual, open L-type Ca2 + channel
Palabras Clave: Células cardíacas
Receptores de calcio
ISSN: 0036-8075
Revisión por Pares: SI
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/25016
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:DEP06 - Artículos de revista

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