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Phase-Amplitude Coupling Analysis of Spontaneous EEG Activity in Alzheimer’s Disease
39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Año del Documento
This study was aimed at exploring phaseamplitude coupling (PAC) patterns of neural activity in dementia due to Alzheimer’s disease (AD). For this task, five minutes of spontaneous electroencephalographic (EEG) activity from 22 patients with mild AD and 16 cognitively healthy controls were studied. To assess PAC patterns, phase-locking value was computed between the phase of low frequencies and the power of high frequencies within each sensor. Our results showed that high-frequency gamma power is phase-locked to the alpha peak in EEG signals. Furthermore, statistically significant differences (p<0.05, permutation test) between patients with mild AD and elderly controls were observed at the lower left temporo-parietal area, suggesting that early stages of AD elicit a region-specific decrease of PAC in the neural activity.
This research was partially supported by: the ‘Ministerio de Economía y Competitividad (MINECO)’ and FEDER under project TEC2014-53196-R; and the ‘Consejería de Educación de la Junta de Castilla y León’ under project VA037U16. P. Núñez is in receipt of a ‘Promoción de empleo joven e implantación de la Garantía Juvenile n I+D+i’ grant from MINECO and the University of Valladolid. J. Gómez-Pilar is in receipt of a PIF-UVA grant from the University of Valladolid. J. Poza, C. Gómez, M. García, P. Núñez, J. Gomez-Pilar and R. Hornero are with the Biomedical Engineering Group (GIB), Signal Theory and Communications Department, University of Valladolid, Paseo de Belén 15, 47011-Valladolid, Spain (phone: +34 983423000, ext. 5569; fax: +34 983423667; e-mail: firstname.lastname@example.org). A. Bachiller is with the Research Centre for Biomedical Engineering (CREB), Polytechnic University of Catalonia, Barcelona, Spain (e-mail: email@example.com). M. A. Tola-Arribas is with the Department of Neurology, Río Hortega University Hospital, Valladolid, Spain (e-mail: firstname.lastname@example.org). M. Cano is with the Department of Clinical Neurophysiology, Río Hortega University Hospital, Valladolid, Spain (e-mail: email@example.com).