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Por favor, use este identificador para citar o enlazar este ítem: http://uvadoc.uva.es/handle/10324/31364
Título: Bispectral Analysis to Enhance Oximetry as a Simplified Alternative for Pediatric Sleep Apnea Diagnosis
Autor: Gutiérrez-Tobal, Gonzalo C
Kheirandish-Gozal, Leila
Vaquerizo-Villar, Fernando
Álvarez, Daniel
Barroso-García, Verónica
Crespo, Andrea
del Campo, Félix
Gozal, David
Hornero, Roberto
Congreso: 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Año del Documento: 2018
Descripción: Producción Científica
Resumen: This study aims at assessing the bispectral analysis of blood oxygen saturation (SpO2) from nocturnal oximetry to help in pediatric sleep apnea-hypopnea syndrome (SAHS) diagnosis. Recent studies have found excessive redundancy in the SAHS-related information usually extracted from SpO2, while proposing only two features as a reduced set to be used. On the other hand, it has been suggested that SpO2 bispectral analysis is able to provide complementary information to common anthropometric, spectral, and clinical variables. We address these novel findings to assess whether bispectrum provides new non-redundant information to help in SAHS diagnosis. Thus, we use 981 pediatric SpO2 recordings to extract both the reduced set of features recently proposed as well as 9 bispectral features. Then, a feature selection method based on the fast correlation-based filter and bootstrapping is used to assess redundancy among all the features. Finally, the non-redundant ones are used to train a Bayesian multi-layer perceptron neural network (BY-MLP) that estimate the apnea-hypopnea index (AHI), which is the diagnostic reference variable. Bispectral phase entropy was found complementary to the two previously recommended features and a BY-MLP model trained with the three of them reached high agreement with actual AHI (intra-class correlation coefficient = 0.889). Estimated AHI also showed high diagnostic ability, reaching 82.1%, 81.9%, and 90.3% accuracies and 0.814, 0.880, and 0.922 area under the receiver-operating characteristics curve for three common AHI thresholds: 1 e/h, 5 e/h, and 10 e/h, respectively. These results suggest that the information extracted from the bispectrum of SpO2 can improve the diagnostic performance of the oximetry test.
Patrocinador: *This work was supported ‘Ministerio de Economía y Competitividad’ and ‘European Regional Development Fund’ under projects DPI2017-84280-R, TEC2014-53196-R, and RTC-2015-3446-1, by ‘Consejería de Educación de la Junta de Castilla y León and FEDER’ under project VA037U16, by ‘European Commission’ and ‘European Regional Development Fund’ under project ‘POCTEP 0378_AD_EEGWA_2_P’, and the project 66/2016 de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR). F. Vaquerizo-Villar was in receipt of a ‘Ayuda para contratos predoctorales para la Formación de Profesorado Universitario (FPU)’ grant from the Ministerio de Educación, Cultura y Deporte. V. Barroso-García was in a receipt of a ‘Ayuda para financiar la contratación predoctoral de personal investigador’ grant from the Consejería de Educación de la Junta de Castilla y León and the European Social Fund. D. Álvarez was in receipt of a Juan de la Cierva grant from MINECO. L. Kheirandish-Gozal was supported by National Institutes of Health grant HL130984. G. C. Gutiérrez-Tobal, F. Vaquerizo-Villar, V. Barroso-García and R. Hornero, are with the Biomedical Engineering Group, Universidad de Valladolid, Spain (e-mail: gonzalo.gutierrez@gib.tel.uva.es). D. Álvarez, F. del Campo, and A. Crespo are with the Hospital Universitario Río Hortega of Valladolid, Spain (e-mail: fsas@telefonica.net). L. Kheirandish-Gozal and D. Gozal are with the Section of Sleep Medicine, Dept. of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, 60637, USA (e-mail: dgozal@uchicago.edu).
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/31364
Derechos: info:eu-repo/semantics/restrictedAccess
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