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Title: Random and oriented electrospun fibers based on a multicomponent, in situ clickable elastin-like recombinamer system for dermal tissue engineering
Authors: González de Torre, Israel
Ibáñez Fonseca, Arturo
Quintanilla Sierra, Luis
Alonso Rodrigo, Matilde
Rodríguez Cabello, José Carlos
Issue Date: 2018
Publisher: Elsevier
Description: Producción Científica
Citation: Acta Biomaterialia, 2018, Volume 72, Pages 137-149
Abstract: Herein we present a system to obtain fibers from clickable elastin-like recombinamers (ELRs) that crosslink in situ during the electrospinning process itself, with no need for any further treatment to stabilize them. These ELR-click fibers are completely stable under in vitro conditions. A wrinkled fiber morphology is obtained. In addition to a random fiber orientation, oriented fibers with a high degree of alignment and coherence can also be obtained by using a rotational electrode. The production of multicomponent fibers means that different functionalities, such as cell-adhesion domains (RGD peptides), can be incorporated into them. In a subsequent study, two main cell lines present in the dermis and epidermis, namely keratinocytes and fibroblasts, were cultured on top of the ELR-click fibers. Adhesion, proliferation, fluorescence, immunostaining and histology studies showed the cytocompatibility of these scaffolds, thus suggesting their possible use for wound dressings in skin tissue engineering applications.
Classification: Elastina
Ingeniería de tejidos dérmicos
Dermal tissue engineering
ISSN: 1742-7061
Peer Review: SI
Sponsor: Ministerio de Economía, Industria y Competitividad (Projects MAT2015-68901-R, MAT2016-78903-R, PCIN-2015-010)
Junta de Castilla y León (programa de apoyo a proyectos de investigación - Ref. VA015U16)
European Commission (ELASTISLET No 646075, BIOGEL No 642687)
Publisher Version:
Language: eng
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:BIOFORGE - Artículos de revista

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