|Title: ||Self-Assembling Elastin-Like Hydrogels for Timolol Delivery: Development of an Ophthalmic Formulation Against Glaucoma|
|Authors: ||Fernández Colino, Alicia|
Quinteros, Daniela A.
Palma, Santiago D.
Arias Vallejo, F. J.
|Issue Date: ||2017|
|Publisher: ||American Chemical Society|
|Description: ||Producción Científica|
|Citation: ||Molecular Pharmaceutics, 2017, 14 (12), pp 4498–4508|
|Abstract: ||This work focuses on improving the effectiveness of current therapies against glaucoma by incorporating self-assembled polymers into the ophthalmic formulation. To that end, we first studied the influence of the dispersing medium on the mechanical performance of self-assembling elastin-like (EL) and silk-elastin-like (SEL) hydrogels by conducting rheological tests. These polymers were subsequently incorporated into the antiglaucoma formulation, which contains timolol maleate (TM) as active ingredient, and in vivo tests, namely adhesion tests and intraocular pressure measurements (IOP), were performed in New Zealand rabbits. An enhanced reduction in IOP due to the presence of the polymers was observed. Moreover, differences in the effectiveness between both EL- and SEL-hydrogels, which can be explained on the basis of the different rheological properties displayed by these two systems, were also encountered. The results point to the potential of this system as a basis for the development of an ophthalmic formulation against glaucoma.|
|Peer Review: ||SI|
|Sponsor: ||European Social Fund (ESF) and European Regional Development Fund (ERDF)|
Comisión Europea (proyectos NMP-2014-646075, HEALTH-F4-2011-278557, PITN-GA-2012-317306, y MSCA-ITN-2014-642687)
Ministerio de Economía, Industria y Competitividad (Projects MAT2015-68901-R, MAT2016-79435-R and MAT2016-78903-R)
Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13 y VA313U14)
CIBER-BBN, Instituto de Salud Carlos III a través de la "Red de Medicina Regenerativa y Terapia Celular de Castilla y León", con el apoyo del “Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) y la Universidad Nacional de Córdoba (Argentina)
|Publisher Version: ||https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.7b00615|
|Rights Owner: ||© 2017 American Chemical Society|
|Appears in Collections:||BIOFORGE - Artículos de revista|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.