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dc.contributor.authorGonzález Obeso, Constancio
dc.contributor.authorGirotti, Alessandra
dc.contributor.authorRodríguez Cabello, José Carlos 
dc.date.accessioned2019-04-02T11:27:51Z
dc.date.issued2019
dc.identifier.citationActa Biomaterialia, 2019, Volume 88, Pages 241-250es
dc.identifier.issn1742-7061es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/35317
dc.descriptionProducción Científicaes
dc.description.abstractThe development of mucoadhesive materials is of great interest and is also a major challenge. Being adsorption sites, mucosae are suitable targets for drug delivery, but as defensive barriers they are complex biological surfaces to interact with, mainly due to their protective mucus layer. As such, first- and second-generation mucoadhesives focused on material-mucus interactions, whereas the third generation of mucoadhesives introduced structural motifs that are able to interact with the cells beneath the mucus layer. The combination of different prerequisites (water solubility, soft gel formation at body temperature and able to interact with the mucus) in a single molecule is easily achieved using elastin-like recombinamers (ELRs) given their multiple block design. Moreover, we have been able to introduce a short amino-acid sequence known as T7 that is able to bind to transferrin receptors in the epithelial cell layer. The T7 sequence enhances the cell-binding properties of the mucoadhesive ELR (MELR), as demonstrated using a Caco-2 epithelial cell model. In vivo experiments confirmed the mucoadhesive properties found in vitro.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.classificationReceptor de Transferrinaes
dc.subject.classificationTransferrin receptores
dc.subject.classificationElastinaes
dc.subject.classificationElastines
dc.titleA transferrin receptor-binding mucoadhesive elastin-like recombinamer: In vitro and in vivo characterizationes
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2019 Elsevieres
dc.identifier.doihttps://doi.org/10.1016/j.actbio.2019.02.027es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1742706119301400es
dc.peerreviewedSIes
dc.description.embargo2021-02-19es
dc.description.lift2021-02-19
dc.description.projectMinisterio de Economía, Industria y Competitividad (Projects PCIN-2015-010, MAT2015-68901-R, MAT2016-78903-R, MAT2016-79435-R)es
dc.description.projectJunta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA015U16)es
dc.description.projectEuropean Commission (NMP-2014-646075)es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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