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Please use this identifier to cite or link to this item: http://uvadoc.uva.es/handle/10324/35317
Title: A transferrin receptor-binding mucoadhesive elastin-like recombinamer: In vitro and in vivo characterization
Authors: González Obeso, Constancio
Girotti, Alessandra
Rodríguez Cabello, José Carlos
Issue Date: 2019
Publisher: Elsevier
Description: Producción Científica
Citation: Acta Biomaterialia, 2019, Volume 88, Pages 241-250
Abstract: The development of mucoadhesive materials is of great interest and is also a major challenge. Being adsorption sites, mucosae are suitable targets for drug delivery, but as defensive barriers they are complex biological surfaces to interact with, mainly due to their protective mucus layer. As such, first- and second-generation mucoadhesives focused on material-mucus interactions, whereas the third generation of mucoadhesives introduced structural motifs that are able to interact with the cells beneath the mucus layer. The combination of different prerequisites (water solubility, soft gel formation at body temperature and able to interact with the mucus) in a single molecule is easily achieved using elastin-like recombinamers (ELRs) given their multiple block design. Moreover, we have been able to introduce a short amino-acid sequence known as T7 that is able to bind to transferrin receptors in the epithelial cell layer. The T7 sequence enhances the cell-binding properties of the mucoadhesive ELR (MELR), as demonstrated using a Caco-2 epithelial cell model. In vivo experiments confirmed the mucoadhesive properties found in vitro.
Classification: Receptor de Transferrina
Transferrin receptor
Elastina
Elastin
ISSN: 1742-7061
Peer Review: SI
DOI: https://doi.org/10.1016/j.actbio.2019.02.027
Sponsor: Ministerio de Economía, Industria y Competitividad (Projects PCIN-2015-010, MAT2015-68901-R, MAT2016-78903-R, MAT2016-79435-R)
Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA015U16)
European Commission (NMP-2014-646075)
Publisher Version: https://www.sciencedirect.com/science/article/pii/S1742706119301400
Rights Owner: © 2019 Elsevier
Language: eng
URI: http://uvadoc.uva.es/handle/10324/35317
Rights: info:eu-repo/semantics/openAccess
Confiscate2021-02-19
Appears in Collections:BIOFORGE - Artículos de revista

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