Functions of sensory TRP channels in vascular responses to chemical and thermal stimuli

Abstract

Fine-tuned regulation of the arterial pressure is an essential physiological process determined by two important parameters, cardiac output (CO) and total peripheral resistance (TPR). The deregulation of the blood pressure can lead to cause severe vascular disorders over time and even sudden death. Multiple pathways including the autonomic nervous system, renin–angiotensin system, aldosterone, vasoactive substances and vascular responses to external changes affect CO and TPR to tightly regulate vascular functions and thus ensure appropriate blood flow along the body. Arteries with small diameters, also called resistance arteries, contribute significantly to the regulation and creation of resistance to blood flow in order to maintain a normal arterial pressure.