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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/45345

    Título
    Clinical and tear cytokine profiles after advanced surface ablation refractive surgery: A six-month follow-up
    Autor
    González García, María JesúsAutoridad UVA Orcid
    Murillo, Giovanna M.
    Pinto Fraga, Francisco JoséAutoridad UVA Orcid
    García, Noelia
    Fernández Martínez, ItziarAutoridad UVA Orcid
    Maldonado López, Miguel JoséAutoridad UVA Orcid
    Calonge, MargaritaAutoridad UVA Orcid
    Enriquez De Salamanca Aladro, AmaliaAutoridad UVA Orcid
    Año del Documento
    2020
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Exp Eye Res . 2020 Apr;193:107976
    Résumé
    Neuropathic dry eye is one of the most frequently seen complications after corneal refractive surgery, however, its incidence decreases in a significant manner along the first six months postoperative, reaching between 10 and 45% incidence. However, little is known on the inflammatory status of the ocular surface during this recovery process. We aim to analyze the clinical and tear molecule concentration changes along six months after advanced surface ablation for myopia correction, in a prospective study including 18 eyes of 18 subjects who bilaterally underwent advanced surface ablation corneal refractive surgery. Clinical variables (uncorrected distance visual acuity, symptoms, conjunctival hyperemia, tear osmolarity, tear stability, corneal fluorescein staining, conjunctival lissamine staining, Schirmer test, and corneal esthesiometry) and a panel of 23 pro and anti-inflammatory cytokines/chemokines concentration in tears preoperatively and at 1, 3 and 6 months postoperatively were evaluated. We found that uncorrected distance visual acuity improved significantly from baseline at 1-month visit, symptoms improved and tear osmolarity decreased significantly from baseline at 3-month visit and there was a decrease in mechanical corneal threshold between 1-month and 3- and 6-month visits. Regarding tear molecules, IL-4, IL-5, IL-6, IL-13, IL-17A, and IFN-γ tear levels were significantly increased at all the three visits, compared to preoperative levels at V0; IL-2 and VEGF were also significantly increased at 1-month and 6-month visits, but not at 3-month visit, whereas IL-9 IL-10 and IL-12 were only significantly increased at 6-month visit. Although we found that there is a recovery in clinical variables at 6 months postoperatively (i.e. neuropathic dry eye was not developed in the sample), ocular surface homeostasis is not completely restored, as it can be seen by the changes in concentration of some pro and anti-inflammatory molecules measured in tears.
    Palabras Clave
    Surface ablation
    Ablación en superficie
    Cytokines
    Citoquinas
    Dry eye disease
    Síndrome del ojo seco
    Ocular inflammation
    Inflamación ocular
    Refractive surgery
    Cirugía refractiva
    ISSN
    0014-4835
    Revisión por pares
    SI
    DOI
    10.1016/j.exer.2020.107976
    Patrocinador
    Partially supported by national grant (AES) from the Ministry of 465 Economy and Competitiveness, Madrid, Spain, SAF2016-77080 AEI/FEDER, UE
    Version del Editor
    https://www.sciencedirect.com/science/article/pii/S0014483519304683
    Propietario de los Derechos
    © Todos los derechos reservados. Propietario de los derechos Elsevier
    Idioma
    spa
    URI
    http://uvadoc.uva.es/handle/10324/45345
    Tipo de versión
    info:eu-repo/semantics/acceptedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • IOBA - Artículos de revista [82]
    Afficher la notice complète
    Fichier(s) constituant ce document
    Nombre:
    González-Garcia et al EER 2019 Revision 4_V0.pdf
    Tamaño:
    3.784Mo
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