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Please use this identifier to cite or link to this item: http://uvadoc.uva.es/handle/10324/4620
Title: Early embryonic brain development in rats requieres the trophic influence of cerebrospinal fluid
Authors: Martín, C.
Alonso Revuelta, María Isabel
Santiago, C.
Moro Balbás, José Antonio
Mano Bonín, Aníbal de la
Carretero, R.
Gato Casado, Ángel Luis
Issue Date: 2009
Publisher: Elsevier
Description: Producción Científica
Citation: International Journal of Developmental Neuroscience, 2009, vol. 27. p. 733-740
Abstract: Particularly evCerebrospinal fluid has shown itself to be an essential brain component during development. This is parident at the earliest stages of development where a lot of research, performed mainly in chick embryos, supports the evidence that cerebrospinal fluid is involved in different mechanisms controlling brain growth and morphogenesis, by exerting a trophic effect on neuroepithelial precursor cells (NPC) involved in controlling the behaviour of these cells. Despite it being known that cerebrospinal fluid in mammals is directly involved in corticogenesis at fetal stages, the influence of cerebrospinal fluid on the activity of NPC at the earliest stages of brain development has not been demonstrated. Here, using ‘‘in vitro’’ organotypic cultures of rat embryo brain neuroepithelium in order to expose NPC to or deprive them of cerebrospinal fluid, we show that the neuroepithelium needs the trophic influence of cerebrospinal fluid to undergo normal rates of cell survival, replication and neurogenesis, suggesting that NPC are not self-sufficient to induce their normal activity. This data shows that cerebrospinal fluid is an essential component in chick and rat early brain development, suggesting that its influence could be constant in higher vertebrates.
Keywords: Tubo neural
Embriología
Neurogénesis
ISSN: 0736-5748
Peer Review: SI
Rights Owner: Elsevier
Language: eng
URI: http://uvadoc.uva.es/handle/10324/4620
Rights: info:eu-repo/semantics/openAccess
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Appears in Collections:DEP04 - Artículos de revista

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