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Title: Cerebroespinalfluid control of neurogenesis induced by retinoic acid during early brain development
Authors: Alonso Revuelta, María Isabel
Martín, C.
Carnicero Gila, Estela María
Bueno, D.
Gato Casado, Ángel Luis
Issue Date: 2011
Publisher: Wiley
Description: Producción Científica
Citation: Developmental Dynamics, 2011
Abstract: Embryonic-cerebrospinal fluid (E-CSF) plays crucial roles in early brain development including the control of neurogenesis. Although FGF2 and lipoproteins present in the E-CSF have previously been shown to be involved in neurogenesis, the main factor triggering this process remains unknown. E-CSF contains all-trans-retinol and retinol-binding protein involved in the synthesis of retinoic acid (RA), a neurogenesis inducer. In early chick embryo brain, only the mesencephalic-rombencephalic isthmus (IsO) is able to synthesize RA. Here we show that in chick embryo brain development: (1) E-CSF helps to control RA synthesis in the IsO by means of the RBP and all-trans-retinol it contains; (2) E-CSF has retinoic acid activity, which suggests it may act as a diffusion pathway for RA; and (3) the influence of E-CSF on embryonic brain neurogenesis is to a large extent due to its involvement in RA synthesis. These data help to understand neurogenesis from neural progenitor cells
Keywords: Neurología del desarrollo
ISSN: 1058-8388
Peer Review: SI
DOI: 10.1002/dvdy.22657
Language: eng
Rights: info:eu-repo/semantics/embargoedAccess
Appears in Collections:DEP04 - Artículos de revista

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