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Título: All-trans retinol and retinol-binding protein from embryonic cerebrospinal £uid exhibit dynamic behaviour during early central nervous system development
Autor: Parada, Carolina
Gato Casado, Ángel Luis
Bueno, David
Año del Documento: 2008
Editorial: Lippincott Williams and Wilkins
Descripción: Producción Científica
Documento Fuente: Developmental Neuroscience, June 2008, vol. 19, n. 9. p. 945-950
Resumen: Embryonic cerebrospinal £uid (E-CSF) is involved in the regulation of survival, proliferation and neurogenesis of neuroectodermal progenitor cells, aswell as in the control ofmesencephalic gene expression in collaboration with the isthmic organizer. Recently, we showed the presence of retinol-binding protein (RBP) within the E-CSF proteome.RBP is an all-trans retinol carrier, amolecule that can be metabolized into retinoic acid, a morphogen involved in central nervous system (CNS) morphogenesis and patterning. Here we demonstrate the presence of all-trans retinol within the E-CSF and analyse the dynamics of RBP and all-trans retinolwithin this £uid, as well as the expression of retinoic acid-synthesizing enzymes during early CNS development. Our results suggest a relationship between the dynamics of these molecules and the early events of CNS patterning.
Materias (normalizadas): Fluidos orgánicos
Retinol
Embriología humana
Cerebro - Desarrollo
ISSN: 0378-5866
Revisión por Pares: SI
Propietario de los Derechos: Lippincott Williams and Wilkins
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/5797
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:DEP04 - Artículos de revista

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