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Por favor, use este identificador para citar o enlazar este ítem: http://uvadoc.uva.es/handle/10324/5943
Título: Effect of the TNF -308 G/A Polymorphism on the Changes Produced by Atorvastatin in Bone Mineral Density in Patients with Acute Coronary Syndrome
Autor: Pérez Castrillón, José Luis
Vega, Gemma
Abad, Laura
Sanz-Cantalapiedra, Alberto
González Sagrado, Manuel
Luis Román, Daniel Antonio de
Dueñas Laita, Antonio
Año del Documento: 2008
Editorial: Karger
Descripción: Producción Científica
Documento Fuente: Annals of Nutrition and Metabolism, 2008, vol. 53, p. 117-121
Resumen: Aims: To evaluate the effect of atorvastatin on bone mass and markers of bone remodeling in patients with acute coronary syndrome depending on the tumor necrosis factor- (TNF )-308 G/A polymorphism. Methods: Sixty-two patients with acute coronary syndrome (35 males and 27 females), average age 60 8 10 years, were included. Patients were given low (10–20 mg) and high doses (40–80 mg) atorvastatin according to their baseline levels of cholesterol and triglycerides and their index of vascular risk. Patients were studied during hospital admission (baseline) and at 12 months of follow-up. Cholesterol, triglycerides, total calcium, phosphorus, magnesium, osteocalcin and urinary deoxypyridinoline were determined in all patients at baseline and at 12 months of follow-up. Densitometric studies were conducted in the lumbar spine (L 2 –L 4 ), femoral neck and trochanter using an X-ray densitometer. The TNF -308 G/A polymorphism was determined by the polymerase chain reaction. Results: Forty-five patients were homozygous for G/G (72.5%) and 17 were heterozygous for G/A (27.5%). The prevalence of osteoporosis (T score ^ 2.5 in the lumbar spineand/or hip) was 33% for the G/G genotype and 35% for the G/A genotype, with no statistically significant differences between groups. There was a statistically significant increase in bone mineral density (BMD) in the lumbar spine (1.107 8 0.32 vs. 1.129 8 0.23; p = 0.0001) in patients with the G/G genotype. No changes were observed in patients with the G/A genotype. Conclusion: In patients with acute coronary syndrome, atorvastatin increases lumbar spine BMD solely in patients with the G/G genotype of the TNF -308 G/A polymorphism.
Materias (normalizadas): Huesos - Enfermedades
Cardiovascular, Aparato - Enfermedades
ISSN: 0250-6807
Revisión por Pares: SI
DOI: 10.1159/000170886
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/5943
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:DEP52 - Artículos de revista

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