|Título: ||Polymorphisms of the WNT10B Gene, Bone Mineral Density, and Fractures in Postmenopausal Women|
|Autor: ||Pérez Castrillón, José Luis|
Olmos, José M.
Nan, Daniel N.
Pérez-Núñez, María I.
Riancho, José A.
|Año del Documento: ||2009|
|Editorial: ||Springer Science+Business Media|
|Descripción: ||Producción Científica|
|Documento Fuente: ||Calcified Tissue International, 2009, vol. 85, p. 113-118|
|Resumen: ||Wnt ligands are important regulators of skeletal
homeostasis. Wnt10B tends to stimulate the differentiation
of common mesenchymal precursors toward the osteoblastic
lineage, while inhibiting adipocytic differentiation.
Hence, we decided to explore the association of WNT10B
allelic variants with bone mineral density and osteoporotic
fractures. A set of tag SNPs capturing most common
variations of the WNT10B gene was genotyped in 1438
Caucasian postmenopausal women, including 146 with
vertebral fractures and 432 with hip fractures. We found no
association between single SNPs and spine or hip bone
mineral density (BMD). In the multilocus analysis, some
haplotypes showed a slight association with spine BMD
(P = 0.03), but it was not significant after multiple-test
correction. There was no association between genotype and
vertebral or hip fractures. Transcripts of WNT10B and
other Wnt ligands were detected in human bone samples by
real-time PCR. However, there was no relationship
between genotype and RNA abundance. Thus, WNT10B is
expressed in the bone microenvironment and may be an
important regulator of osteoblastogenesis, but we have not found evidence for a robust association of common
WNT10B gene allelic variants with either BMD or fractures
in postmenopausal women.|
|Materias (normalizadas): ||Osteoporosis|
|Revisión por Pares: ||SI|
|Aparece en las colecciones:||DEP52 - Artículos de revista|