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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/6102

    Título
    Exon-Intron Structure and Evolution of the Lipocalin Gene Family
    Autor
    Sánchez Romero, DiegoAutoridad UVA Orcid
    Ganfornina Álvarez, María DoloresAutoridad UVA Orcid
    Gutiérrez, Gabriel
    Marín, Antonio
    Año del Documento
    2003
    Editorial
    Society for Molecular Biology and Evolution
    Descripción
    Innovación Educativa
    Documento Fuente
    Molecular Biology and Evolution, 2003, vol. 20, n. 5, p. 775-783
    Résumé
    The Lipocalins are an ancient protein family whose expression is currently confirmed in bacteria, protoctists, plants, arthropods, and chordates. The evolution of this protein family has been assessed previously using amino acid sequence phylogenies. In this report we use an independent set of characters derived from the gene structure (exon-intron arrangement) to infer a new lipocalin phylogeny. We also present the novel gene structure of three insect lipocalins. The position and phase of introns are well preserved among lipocalin clades when mapped onto a protein sequence alignment, suggesting the homologous nature of these introns. Because of this homology, we use the intron position and phase of 23 lipocalin genes to reconstruct a phylogeny by maximum parsimony and distance methods. These phylogenies are very similar to the phylogenies derived from protein sequence. This result is confirmed by congruence analysis, and a consensus tree shows the commonalities between the two source trees. Interestingly, the intron arrangement phylogeny shows that metazoan lipocalins have more introns than other eukaryotic lipocalins, and that intron gains have occurred in the C-termini of chordate lipocalins. We also analyze the relationship of intron arrangement and protein tertiary structure, as well as the relationship of lipocalins with members of the proposed structural superfamily of calycins. Our congruence analysis validates the gene structure data as a source of phylogenetic information and helps to further refine our hypothesis on the evolutionary history of lipocalins.
    Materias (normalizadas)
    Lipocainas
    Calciproteinas
    ISSN
    0737-4038
    Revisión por pares
    SI
    DOI
    10.1093/molbev/msg079
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/6102
    Derechos
    openAccess
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    • DEP06 - Artículos de revista [353]
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcepté là où spécifié autrement, la license de ce document est décrite en tant que Attribution-NonCommercial-NoDerivatives 4.0 International

    Universidad de Valladolid

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