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    • Dpto. Bioquímica y Biología Molecular y Fisiología
    • DEP06 - Artículos de revista
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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/7168

    Título
    Significance of ROS in oxygen sensing in cell systems with sensitivy to ohysiological hypoxia
    Autor
    González Martínez, Constancio
    Sanz Alfayate, Gloria
    Agapito Serrano, María TeresaAutoridad UVA Orcid
    Gómez Niño, María ÁngelesAutoridad UVA Orcid
    Rocher Martín, María AsunciónAutoridad UVA Orcid
    Obeso Cáceres, Ana María de la LuzAutoridad UVA Orcid
    Año del Documento
    2002
    Editorial
    Elsevier
    Documento Fuente
    Respiratory Physiology & Neurobiology 132 (2002) 17–41
    Resumen
    Reactive oxygen species (ROS) are oxygen-containing molecular entities which are more potent and effective oxidizing agents than is molecular oxygen itself. With the exception of phagocytic cells, where ROS play an important physiological role in defense reactions, ROS have classically been considered undesirable byproducts of cell metabolism, existing several cellular mechanisms aimed to dispose them. Recently, however, ROS have been considered important intracellular signaling molecules, which may act as mediators or second messengers in many cell functions. This is the proposed role for ROS in oxygen sensing in systems, such as carotid body chemoreceptor cells, pulmonary artery smooth muscle cells, and erythropoietin-producing cells. These unique cells comprise essential parts of homeostatic loops directed to maintain oxygen levels in multicellular organisms in situations of hypoxia. The present article examines the possible significance of ROS in these three cell systems, and proposes a set of criteria that ROS should satisfy for their consideration as mediators in hypoxic transduction cascades. In none of the three cell types do ROS satisfy these criteria, and thus it appears that alternative mechanisms are responsible for the transduction cascades linking hypoxia to the release of neurotransmitters in chemoreceptor cells, contraction in pulmonary artery smooth muscle cells and erythropoietin secretion in erythropoietin producing cells.
    Materias (normalizadas)
    Neurofisiología
    ISSN
    1569-9048
    Revisión por pares
    SI
    DOI
    10.1016/S1569-9048(02)00047-2
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/7168
    Derechos
    openAccess
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    • DEP06 - Artículos de revista [352]
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