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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/24717

    Título
    Chemotransduction in the carotid body: K+ current modulated by PO2 in type I chemoreceptor cells
    Autor
    López Barneo, José
    López López, José RamónAutoridad UVA Orcid
    Ureña, J.
    González Martínez, Constancio
    Año del Documento
    1988
    Editorial
    American Association for the Advancement of Science
    Descripción
    Producción Científica
    Documento Fuente
    Science, vol. 241. p.580-582.
    Résumé
    The ionic currents of carotid body type 1cells and their possible involvement in the detection of oxygen tension (Po2) in arterial blood are unknown. The electrical properties of these cells were studied with the whole-cell patch clamp technique, and the hypothesis that ionic conductances can bealtered by changes in Po2 was tested. The results show that type 1cells have voltage-dependent sodium, calcium, and potassium channels. Sodium and calcium currents were unaffected by a decrease in Po2 from 150 to 10 millimeters of mercury, whereas, with the same experimental protocol, potassi­ um currents were reversibly reduced by 25 to 50 percent. The effect of hypoxia was independent of internal adenosine triphosphate and calcium. Thus, ionic conductances, and particularly the 02-sensitive potassium current, play a key role in the transduction mechanism of arterial chemoreceptors.
    Palabras Clave
    Cuerpo carotídeo
    Neurotransmisores
    ISSN
    0036-8075
    Revisión por pares
    SI
    Idioma
    spa
    URI
    http://uvadoc.uva.es/handle/10324/24717
    Derechos
    openAccess
    Aparece en las colecciones
    • IBGM - Artículos de revista [78]
    • VASCUMIT - Artículos de revista [47]
    • DEP06 - Artículos de revista [352]
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