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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/24811

    Título
    Elastin-like-recombinamers multilayered nanofibrous scaffolds for cardiovascular applications
    Autor
    Putzu, M.
    González de Torre, IsraelAutoridad UVA Orcid
    Rodríguez Cabello, José CarlosAutoridad UVA Orcid
    Causa, F.
    Netti, P.A.
    Año del Documento
    2016
    Editorial
    IOP Publishing
    Descripción
    Producción Científica
    Documento Fuente
    Biofabrication 8 ( 2016 ) 045009
    Zusammenfassung
    Coronary angioplasty is the most widely used technique for removing atherosclerotic plaques in blood vessels. The regeneration of the damaged intima layer after this treatment is still one of the major challenges in the field of cardiovascular tissue engineering. Different polymers have been used in scaffold manufacturing in order to improve tissue regeneration. Elastin-mimetic polymers are a new class of molecules that have been synthesized and used to obtain small diameter fibers with specific morphological characteristics. Elastin-like polymers produced by recombinant techniques and called elastin-like recombinamers (ELRs) are particularly promising due to their high degree of functionalization. Generally speaking, ELRs can show more complex molecular designs and a tighter control of their sequence than other chemically synthetized polymers Rodriguez Cabello et al (2009 Polymer 50 5159–69, 2011 Nanomedicine 6 111–22). For the fabrication of small diameter fibers, different ELRs were dissolved in 2,2,2-fluoroethanol (TFE). Dynamic light scattering was used to identify the transition temperature and get a deep characterization of the transition behavior of the recombinamers. In this work, we describe the use of electrospinning technique for the manufacturing of an elastic fibrous scaffold; the obtained fibers were characterized and their cytocompatibility was tested in vitro. A thorough study of the influence of voltage, flow rate and distance was carried out in order to determine the appropriate parameters to obtain fibrous mats without beads and defects. Moreover, using a rotating mandrel, we fabricated a tubular scaffold in which ELRs containing different cell adhesion sequences (mainly REDV and RGD) were collected. The stability of the scaffold was improved by using genipin as a crosslinking agent. Genipin-ELRs crosslinked scaffolds show a good stability and fiber morphology. Human umbilical vein endothelial cells were used to assess the in vitro bioactivity of the cell adhesion domains within the backbone of the ELRs.
    Palabras Clave
    Angioplastia coronaria
    Revisión por pares
    SI
    DOI
    10.1088/1758-5090/8/4/045009
    Patrocinador
    info:eu-repo/grantAgreement/EC/H2020/278557
    Version del Editor
    http://iopscience.iop.org/article/10.1088/1758-5090/8/4/045009/meta
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/24811
    Derechos
    openAccess
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    • BIOFORGE - Artículos de revista [89]
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    Elastin-Like Scaffolds.pdf
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