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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/30409

    Título
    Biocompatibility of two model elastin‐like recombinamer‐based hydrogels formed through physical or chemical cross‐linking for various applications in tissue engineering and regenerative medicine
    Autor
    Ibáñez Fonseca, Arturo
    Ramos, Teresa L.
    González de Torre, IsraelAutoridad UVA Orcid
    Sánchez Abarca, Luis Ignacio
    Muntión, Sandra
    Arias Vallejo, Francisco JavierAutoridad UVA Orcid
    Cañizo, María Consuelo del
    Alonso Rodrigo, MatildeAutoridad UVA Orcid
    Sánchez Guijo, Fermín
    Rodríguez Cabello, José CarlosAutoridad UVA Orcid
    Año del Documento
    2018
    Editorial
    Wiley
    Descripción
    Producción Científica
    Documento Fuente
    Journal of Tissue Engineering and Regenerative Medicine, 2018, Volume12, Issue3, Pages e1450-e1460
    Resumen
    Biocompatibility studies, especially innate immunity induction, in vitro and in vivo cytotoxicity, and fibrosis, are often lacking for many novel biomaterials including recombinant protein‐based ones, such as elastin‐like recombinamers (ELRs), and has not been extensively explored in the scientific literature, in contrast to traditional biomaterials. Herein, we present the results from a set of experiments designed to elucidate the preliminary biocompatibility of 2 types of ELRs that are able to form extracellular matrix‐like hydrogels through either physical or chemical cross‐linking both of which are intended for different applications in tissue engineering and regenerative medicine. Initially, we present in vitro cytocompatibility results obtained upon culturing human umbilical vein endothelial cells on ELR substrates, showing optimal proliferation up to 9 days. Regarding in vivo cytocompatibility, luciferase‐expressing hMSCs were viable for at least 4 weeks in terms of bioluminescence emission when embedded in ELR hydrogels and injected subcutaneously into immunosuppressed mice. Furthermore, both types of ELR‐based hydrogels were injected subcutaneously in immunocompetent mice and serum TNFα, IL‐1β, IL‐4, IL‐6, and IL‐10 concentrations were measured by enzyme‐linked immunosorbent assay, confirming the lack of inflammatory response, as also observed upon macroscopic and histological evaluation. All these findings suggest that both types of ELRs possess broad biocompatibility, thus making them very promising for tissue engineering and regenerative medicine‐related applications.
    Palabras Clave
    Ingeniería de tejidos
    Medicina regenerativa
    Tissue engineering
    Regenerative medicine
    ISSN
    1932-6254
    Revisión por pares
    SI
    DOI
    10.1002/term.2562
    Patrocinador
    European Commission (NMP-2014-646075, HEALTH-F4-2011-278557, PITN-GA-2012-317306 and MSCA-ITN-2014-642687)
    Ministerio de Economía, Industria y Competitividad (Projects MAT2016-78903-R, MAT2016-79435-R, MAT2013-42473-R, MAT2013-41723-R and MAT2012-38043)
    Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref.VA244U13 and VA313U14)
    Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León
    Instituto de Salud Carlos III (grant RD12/0019/0017 )
    Fundação para a Ciência e Tecnologia (SFRH/BD/86451/ 2012)
    Version del Editor
    https://onlinelibrary.wiley.com/doi/abs/10.1002/term.2562
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/30409
    Derechos
    openAccess
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    • BIOFORGE - Artículos de revista [89]
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    Universidad de Valladolid

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