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dc.contributor.authorSantos García, María Mercedes 
dc.contributor.authorSerrano Dúcar, Sofía
dc.contributor.authorGonzález Valdivieso, Juan
dc.contributor.authorVallejo Vicente, Reinaldo
dc.contributor.authorGirotti, Alessandra
dc.contributor.authorCuadrado Curto, María Purificación 
dc.contributor.authorArias Vallejo, Francisco Javier 
dc.date.accessioned2019-04-03T11:35:42Z
dc.date.available2019-04-03T11:35:42Z
dc.date.issued2018
dc.identifier.citationCurrent Medicinal Chemistry, 2018. 25 p.es
dc.identifier.issn0929-8673es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/35328
dc.descriptionProducción Científicaes
dc.description.abstractProtein-based polymers are some of the most promising candidates for a new generation of innovative biomaterials as recent advances in genetic-engineering and biotechnological techniques mean that protein-based biomaterials can be designed and constructed with a high degree of complexity and accuracy. Moreover, their sequences, which are derived from structural protein-based modules, can easily be modified to include bioactive motifs that improve their functions and material-host interactions, thereby satisfying fundamental biological requirements. The accuracy with which these advanced polypeptides can be produced, and their versatility, self-assembly behavior, stimuli-responsiveness and biocompatibility, means that they have attracted increasing attention for use in biomedical applications such as cell culture, tissue engineering, protein purification, surface engineering and controlled drug delivery. The biopolymers discussed in this review are elastin-derived protein-based polymers which are biologically inspired and biomimetic materials. This review will also focus on the design, synthesis and characterization of these genetically encoded polymers and their potential utility for controlled drug and gene delivery, as well as in tissue engineering and regenerative medicine.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherBenthan Sciencees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.classificationBiomaterialeses
dc.subject.classificationBiomaterialses
dc.subject.classificationElastinaes
dc.subject.classificationElastines
dc.subject.classificationIngeniería genéticaes
dc.subject.classificationGenetic engineeringes
dc.subject.classificationAplicaciones biomédicases
dc.subject.classificationBiomedical Applicationses
dc.titleGenetically Engineered Elastin-based Biomaterials for Biomedical Applicationses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doihttps://doi.org/10.2174/0929867325666180508094637es
dc.relation.publisherversionhttp://www.eurekaselect.com/161911/articlees
dc.peerreviewedSIes
dc.description.projectEuropean Social Fund (ESF) and European Regional Development Fund (ERDF)es
dc.description.projectEU (NMP-2014-646075, HEALTH-F4-2011-278557, PITN-GA-2012-317306 and MSCA-ITN-2014-642687)es
dc.description.projectMinisterio de Economía, Industria y Competitividad (Projects MAT2015-68901-R, MAT2016-79435-R and MAT2016-78903-R)es
dc.description.projectJunta de Castilla y León (programa de apoyo a proyectos de investigación - Ref. Projects VA244U13 and VA313U14)es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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