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Título
Trends in the design and use of elastin-like recombinamers as biomaterials
Año del Documento
2019
Editorial
Elsevier
Descripción
Producción Científica
Documento Fuente
Matrix Biology, 2019, vol. 84. p. 111-126
Abstract
Elastin-like recombinamers (ELRs), which derive from one of the repetitive domains found in natural elastin, have been intensively studied in the last few years from several points of view. In this mini review, we discuss all the recent works related to the investigation of ELRs, starting with those that define these polypeptides as model intrinsically disordered proteins or regions (IDPs or IDRs) and its relevance for some biomedical applications. Furthermore, we summarize the current knowledge on the development of drug, vaccine and gene delivery systems based on ELRs, while also emphasizing the use of ELR-based hydrogels in tissue engineering and regenerative medicine (TERM). Finally, we show different studies that explore applications in other fields, and several examples that describe biomaterial blends in which ELRs have a key role. This review aims to give an overview of the recent advances regarding ELRs and to encourage further investigation of their properties and applications.
Palabras Clave
Biomaterials
Biomateriales
Elastin-like recombinamers
Recombinantes tipo elastina
Intrinsically disordered proteins
Proteínas intrínsecamente desestructuradas
Drug delivery
Administración de medicamentos
Tissue engineering
Ingeniería de tejidos
ISSN
0945-053X
Revisión por pares
SI
Patrocinador
Comisión Europea (project NMP-2014-646075)
Ministerio de Economía, Industria y Competitividad (projects PCIN-2015-010 / MAT2016-78903-R / BES-2014-069763)
Junta de Castilla y León (project VA317P18)
Ministerio de Economía, Industria y Competitividad (projects PCIN-2015-010 / MAT2016-78903-R / BES-2014-069763)
Junta de Castilla y León (project VA317P18)
Version del Editor
Propietario de los Derechos
© 2019 Elsevier
Idioma
eng
Tipo de versión
info:eu-repo/semantics/submittedVersion
Derechos
openAccess
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