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dc.contributor.authorVilla Pérez, Pablo
dc.contributor.authorMerino Antolín, Beatriz 
dc.contributor.authorFernández Díaz, Cristina María 
dc.contributor.authorCidad Velasco, María Del Pilar 
dc.contributor.authorDomínguez Lobatón, María Carmen 
dc.contributor.authorMoreno Díaz-Calderón, Alfredo 
dc.contributor.authorMuturi, Harrison T.
dc.contributor.authorGhadieh, Hilda E.
dc.contributor.authorLeissring, Malcolm A.
dc.contributor.authorCózar Castellano, Irene 
dc.contributor.authorPerdomo Hernández, Germán
dc.date.accessioned2020-12-21T11:59:14Z
dc.date.available2020-12-21T11:59:14Z
dc.date.issued2018
dc.identifier.citationMetabolism, 2018, vol. 88. p. 1-11es
dc.identifier.issn0026-0495es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/44474
dc.descriptionProducción Científicaes
dc.description.abstractThe role of insulin-degrading enzyme (IDE), a metalloprotease with high affinity for insulin, in insulin clearance remains poorly understood. OBJECTIVE: This study aimed to clarify whether IDE is a major mediator of insulin clearance, and to define its role in the etiology of hepatic insulin resistance.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.classificationInsulin-degrading enzymeses
dc.subject.classificationEncimas degradadoras de insulinaes
dc.subject.classificationInsulin receptorses
dc.subject.classificationReceptores de insulinaes
dc.titleLiver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in micees
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2018 Elsevieres
dc.identifier.doi10.1016/j.metabol.2018.08.001es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0026049518301690?via%3Dihubes
dc.identifier.publicationfirstpage1es
dc.identifier.publicationlastpage11es
dc.identifier.publicationtitleMetabolismes
dc.identifier.publicationvolume88es
dc.peerreviewedSIes
dc.description.projectMinisterio de Economía, Industria y Competitividad (projects AF2014-58702-C2-1-R, SAF2016-77871-C2-1-R, SAF2014-58702-C2-2-R and SAF2016-77871-C2-2-R)es
dc.description.projectNational Institutes of Health (projects R01-DK054254, R01-DK083850, RO1-HL-112248 and R01-GM115617)es
dc.description.projectAmerican Diabetes Association (Career Development Award 7-11-CD-13 t)es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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