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Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice
dc.contributor.authorVilla Pérez, Pablo
dc.contributor.authorMerino Antolín, Beatriz 
dc.contributor.authorFernández Díaz, Cristina María 
dc.contributor.authorCidad Velasco, María del Pilar
dc.contributor.authorDomínguez Lobatón, María Carmen 
dc.contributor.authorMoreno Díaz-Calderón, Alfredo 
dc.contributor.authorMuturi, Harrison T.
dc.contributor.authorGhadieh, Hilda E.
dc.contributor.authorLeissring, Malcolm A.
dc.contributor.authorCózar Castellano, Irene 
dc.contributor.authorPerdomo Hernández, Germán
dc.date.accessioned2020-12-21T11:59:14Z
dc.date.available2020-12-21T11:59:14Z
dc.date.issued2018
dc.identifier.citationMetabolism, 2018, vol. 88. p. 1-11es
dc.identifier.issn0026-0495es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/44474
dc.descriptionProducción Científicaes
dc.description.abstractThe role of insulin-degrading enzyme (IDE), a metalloprotease with high affinity for insulin, in insulin clearance remains poorly understood. OBJECTIVE: This study aimed to clarify whether IDE is a major mediator of insulin clearance, and to define its role in the etiology of hepatic insulin resistance.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.classificationInsulin-degrading enzymeses
dc.subject.classificationEncimas degradadoras de insulinaes
dc.subject.classificationInsulin receptorses
dc.subject.classificationReceptores de insulinaes
dc.titleLiver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in micees
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2018 Elsevieres
dc.identifier.doi10.1016/j.metabol.2018.08.001es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0026049518301690?via%3Dihubes
dc.identifier.publicationfirstpage1es
dc.identifier.publicationlastpage11es
dc.identifier.publicationtitleMetabolismes
dc.identifier.publicationvolume88es
dc.peerreviewedSIes
dc.description.projectMinisterio de Economía, Industria y Competitividad (projects AF2014-58702-C2-1-R, SAF2016-77871-C2-1-R, SAF2014-58702-C2-2-R and SAF2016-77871-C2-2-R)es
dc.description.projectNational Institutes of Health (projects R01-DK054254, R01-DK083850, RO1-HL-112248 and R01-GM115617)es
dc.description.projectAmerican Diabetes Association (Career Development Award 7-11-CD-13 t)es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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