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Título
Molecular epidemiology of enterovirus 71, coxsackievirus A16 and A6 associated with hand, foot and mouth disease in Spain
Autor
Año del Documento
2014
Editorial
Elsevier
Descripción
Producción Científica
Documento Fuente
Clinical Microbiology and Infection,2014, vol. 20, n. 3, p. O150-O156
Resumen
Hand, foot and mouth disease (HFMD) is a childhood illness frequently caused by genotypes belonging to the enterovirus A species,
including coxsackievirus (CV)-A16 and enterovirus (EV)-71. Between 2010 and 2012, several outbreaks and sporadic cases of HFMD
occurred in different regions of Spain. The objective of the present study was to describe the enterovirus epidemiology associated with
HFMD in the country. A total of 80 patients with HFMD or atypical rash were included. Detection and typing of the enteroviruses were
performed directly in clinical samples using molecular methods. Enteroviruses were detected in 53 of the patients (66%). CV-A6 was the
most frequent genotype, followed by CV-A16 and EV-71, but other minority types were also identified. Interestingly, during almost all of
2010, CV-A16 was the only causative agent of HFMD but by the end of the year and during 2011, CV-A6 became predominant, while
CV-A16 was not detected. In 2012, however, both CV-A6 and CV-A16 circulated. EV-71 was associated with HFMD symptoms only in
three cases during 2012. All Spanish CV-A6 sequences segregated into one major genetic cluster together with other European and Asian
strains isolated between 2008 and 2011, most forming a particular clade. Spanish EV-71 strains belonged to subgenogroup C2, as did most of
the European sequences circulated. In conclusion, the recent increase of HFMD cases in Spain and other European countries has been due
to a larger incidence of circulating species A enteroviruses, mainly CV-A6 and CV-A16, and the emergence of new genetic variants of these
viruses.
Materias Unesco
32 Ciencias Médicas
Palabras Clave
Epidemiología molecular
Fiebre aftosa
Enterovirus 71
Coxsackievirus
ISSN
1198-743X
Revisión por pares
SI
Version del Editor
Propietario de los Derechos
© Elsevier
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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