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Early embryonic brain development in rats requieres the trophic influence of cerebrospinal fluid
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International Journal of Developmental Neuroscience, 2009, vol. 27. p. 733-740
Particularly evCerebrospinal ﬂuid has shown itself to be an essential brain component during development. This is parident at the earliest stages of development where a lot of research, performed mainly in chick embryos, supports the evidence that cerebrospinal ﬂuid is involved in different mechanisms controlling brain growth and morphogenesis, by exerting a trophic effect on neuroepithelial precursor cells (NPC) involved in controlling the behaviour of these cells. Despite it being known that cerebrospinal ﬂuid in mammals is directly involved in corticogenesis at fetal stages, the inﬂuence of cerebrospinal ﬂuid on the activity of NPC at the earliest stages of brain development has not been demonstrated. Here, using ‘‘in vitro’’ organotypic cultures of rat embryo brain neuroepithelium in order to expose NPC to or deprive them of cerebrospinal ﬂuid, we show that the neuroepithelium needs the trophic inﬂuence of cerebrospinal ﬂuid to undergo normal rates of cell survival, replication and neurogenesis, suggesting that NPC are not self-sufﬁcient to induce their normal activity. This data shows that cerebrospinal ﬂuid is an essential component in chick and rat early brain development, suggesting that its inﬂuence could be constant in higher vertebrates.
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