The increase in fracture rates and/or problems associated with missing bones due to
accidents or various pathologies generates socio-health problems with a very high impact. Tissue
engineering aims to offer some kind of strategy to promote the repair of damaged tissue or its
restoration as close as possible to the original tissue. Among the alternatives proposed by this
specialty, the development of scaffolds obtained from recombinant proteins is of special importance.
Furthermore, science and technology have advanced to obtain recombinant chimera’s proteins. This
review aims to offer a synthetic description of the latest and most outstanding advances made with
these types of scaffolds, particularly emphasizing the main recombinant proteins that can be used to
construct scaffolds in their own right, i.e., not only to impregnate them, but also to make scaffolds
from their complex structure, with the purpose of being considered in bone regenerative medicine in
the near future.
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