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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/54549

    Título
    Phenotypic characterization of patients developing chronic dry eye and pain after refractive surgery: A cross-sectional study
    Autor
    Vázquez Hernández, AmandaAutoridad UVA
    Martínez Plaza, ElenaAutoridad UVA
    Fernández Martínez, ItziarAutoridad UVA Orcid
    Sobas Abad, Eva MaríaAutoridad UVA
    González García, María JesúsAutoridad UVA Orcid
    Enriquez De Salamanca Aladro, AmaliaAutoridad UVA Orcid
    Ortega, Enrique
    López Miguel, AlbertoAutoridad UVA Orcid
    Calonge, MargaritaAutoridad UVA Orcid
    Año del Documento
    2022
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    The Ocular Surface, 2022, vol. 26, p. 63-74
    Resumen
    Purpose: To describe the clinical characteristics of patients suffering from chronic dry eye (DE) and pain after refractive surgery (RS). Methods: Cross-sectional, observational, single-visit study. DE-, pain- and psychological-related symptoms were evaluated with specific questionnaires. DE-related tests evaluated tear osmolarity, conjunctival hyperemia, Meibomian gland dysfunction, tear stability and production, and ocular surface staining. Corneal mechanical sensitivity (Cochet-Bonnet) was measured pre/post topical anesthesia, and symptomatic variation post-anesthesia (anesthetic challenge test) was recorded. When pain was present, it was further categorized as neuropathic or nociceptive based on published criteria. Results: We recruited 104 patients (39.5 ± 9.5 years). Most, 85.6%, had corneal RS as opposed to intraocular RS. Migraines, anxiety, depression (p < 0.0001), and central sensitization syndromes (p = 0.0214) were more frequent post-RS than pre-RS. Persistent DE-symptoms, severe in 86.5% patients, developed in a range of 0–204 months post-RS. Dryness and pain were the two most frequent symptoms. The only DE-related tests showing abnormal values were tear osmolarity (315.2 ± 17.1 mOsm/L; normal ≤308) and tear break-up time (4.1 ± 2.5 s; normal >7). Corneal sensitivity was 55.4 ± 7.0 mm, and decreased (p < 0.0001) after topical anesthesia, 6.0 ± 10.4 mm. However, it remained pathologically elevated, ≥10 mm in 61 (58.7%) patients. The normal symptomatic post-anesthesia improvement was absent in 58 (55.7%) patients. Ocular pain was present in 82 (78.8%) patients, and it was categorized as neuropathic in 66 (80.5%) of them, 63.5% of the entire cohort. Conclusions: Chronic ocular pain and its neuropathic subtype were diagnosed in 78.8% and 63.5% respectively of patients seeking consultation for persistent symptomatic DE post-RS.
    Palabras Clave
    Cornea
    Córnea
    Dry eye disease
    Ojo seco
    Corneal innervation
    Inervación corneal
    Refractive surgery
    Cirugía refractiva
    ISSN
    1542-0124
    Revisión por pares
    SI
    DOI
    10.1016/j.jtos.2022.07.010
    Patrocinador
    Ministerio de Ciencia, Innovación y Universidades (grants SAF-2016-77080-P and FPU15/01443)
    Junta de Castilla y León - Fondo Social Europeo (grant EDU/1100/2017)
    Version del Editor
    https://www.sciencedirect.com/science/article/pii/S1542012422000659?via%3Dihub
    Propietario de los Derechos
    © 2022 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/54549
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • IOBA - Artículos de revista [80]
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    Nombre:
    Phenotypic-characterization-patients.pdf
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    3.540Mb
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    Attribution-NonCommercial-NoDerivatives 4.0 InternacionalLa licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 Internacional

    Universidad de Valladolid

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