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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/55758

    Título
    Effects of Zinc supplementation on nutritional status in children with chronic kidney disease: A randomized trial
    Autor
    Escobedo Monge, Marlene Fabiola
    Ayala Macedo, Guido
    Sakihara, Graciela
    Peralta, Silvia
    Almaraz Gómez, AnaAutoridad UVA Orcid
    Barrado Esteban, EnriqueAutoridad UVA Orcid
    Marugán de Miguelsanz, José ManuelAutoridad UVA
    Año del Documento
    2019
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Nutrients 2019, vol. 11, n. 11, 2671
    Zusammenfassung
    Background: Zinc is an essential micronutrient for human beings and its deficiency affects their normal growth and development. Objective: The main aim was to evaluate the effect of two doses of zinc supplementation (ZS) on the nutritional status in chronic kidney disease (CKD) children. Methods: A randomized-trial multicentric study was conducted in 48 CKD (23 females) patients under 18-years-old, for a year. At random, participants took 30 or 15 mg/day of ZS, respectively. Anthropometric measurements and biochemical analysis were performed. Hypozincemia was determined by serum zinc concentration (SZC) using atomic absorption spectrophotometry. The positive or negative change in patients’ body mass index (BMI) Z-score, serum albumin, zinc and C-reactive protein (CRP) levels were used to evaluate the effect of ZS. Results: Mean SZC was normal before and after ZS. Despite ZS, there were no significant changes in serum albumin, zinc and CRP levels. A positive and significant association was observed between SZC and serum albumin before (p = 0.000) and after (p = 0.007) ZS. In both groups of ZS, there was a small but positive and significant change in body mass and normalization in BMI Z-score, hypoalbuminemia, hypozincemia and high CRP, especially with 30 mg/day of ZS. Conclusions: Zinc supplementation may be beneficial for nutritional status in children and adolescents with CKD.
    Palabras Clave
    Zinc
    Hypozincemia
    Hipozincemia
    Kidney - Diseases
    Riñones - Enfermedades
    ISSN
    2072-6643
    Revisión por pares
    SI
    DOI
    10.3390/nu11112671
    Version del Editor
    https://www.mdpi.com/2072-6643/11/11/2671
    Propietario de los Derechos
    © 2019 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/55758
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP60 - Artículos de revista [113]
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    Nombre:
    Effects-zinc-supplementation.pdf
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    1.249Mb
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