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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/57504

    Título
    New trends in quantitative assessment of the corneal barrier function
    Autor
    Guimerà Brunet, Anton
    Illa, Xavi
    Traver, Estefania
    Herrero, Carmen
    Maldonado López, Miguel JoséAutoridad UVA Orcid
    Villa, Rosa
    Año del Documento
    2014
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Sensors, 2014, vol. 14, n. 5, p. 8718-8727
    Resumen
    The cornea is a very particular tissue due to its transparency and its barrier function as it has to resist against the daily insults of the external environment. In addition, maintenance of this barrier function is of crucial importance to ensure a correct corneal homeostasis. Here, the corneal epithelial permeability has been assessed in vivo by means of non-invasive tetrapolar impedance measurements, taking advantage of the huge impact of the ion fluxes in the passive electrical properties of living tissues. This has been possible by using a flexible sensor based in SU-8 photoresist. In this work, a further analysis focused on the validation of the presented sensor is performed by monitoring the healing process of corneas that were previously wounded. The obtained impedance measurements have been compared with the damaged area observed in corneal fluorescein staining images. The successful results confirm the feasibility of this novel method, as it represents a more sensitive in vivo and non-invasive test to assess low alterations of the epithelial permeability. Then, it could be used as an excellent complement to the fluorescein staining image evaluation.
    Materias Unesco
    33 Ciencias Tecnológicas
    32 Ciencias Médicas
    Palabras Clave
    Electrical impedance spectroscopy
    Corneal epithelium
    Permeability
    Barrier function
    ISSN
    1424-8220
    Revisión por pares
    SI
    DOI
    10.3390/s140508718
    Patrocinador
    Ministerio de Ciencia e Innovación, projects SAF2009-14724-C02-02
    Ministerio de España de Economía y Competitividad y el Fondo Europeo de Desarrollo Regional, (projects SAF2012-40227-C02-02 e IPT-2012-0438-010000)
    Version del Editor
    https://www.mdpi.com/1424-8220/14/5/8718
    Propietario de los Derechos
    © 2014 The Author(s)
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/57504
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • IOBA - Artículos de revista [83]
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    New-trends-quantitative.pdf
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    Attribution 3.0 UnportedLa licencia del ítem se describe como Attribution 3.0 Unported

    Universidad de Valladolid

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