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Título
New trends in quantitative assessment of the corneal barrier function
Autor
Año del Documento
2014
Editorial
MDPI
Descripción
Producción Científica
Documento Fuente
Sensors, 2014, vol. 14, n. 5, p. 8718-8727
Resumen
The cornea is a very particular tissue due to its transparency and its barrier function as it has to resist against the daily insults of the external environment. In addition, maintenance of this barrier function is of crucial importance to ensure a correct corneal homeostasis. Here, the corneal epithelial permeability has been assessed in vivo by means of non-invasive tetrapolar impedance measurements, taking advantage of the huge impact of the ion fluxes in the passive electrical properties of living tissues. This has been possible by using a flexible sensor based in SU-8 photoresist. In this work, a further analysis focused on the validation of the presented sensor is performed by monitoring the healing process of corneas that were previously wounded. The obtained impedance measurements have been compared with the damaged area observed in corneal fluorescein staining images. The successful results confirm the feasibility of this novel method, as it represents a more sensitive in vivo and non-invasive test to assess low alterations of the epithelial permeability. Then, it could be used as an excellent complement to the fluorescein staining image evaluation.
Materias Unesco
33 Ciencias Tecnológicas
32 Ciencias Médicas
Palabras Clave
Electrical impedance spectroscopy
Corneal epithelium
Permeability
Barrier function
ISSN
1424-8220
Revisión por pares
SI
Patrocinador
Ministerio de Ciencia e Innovación, projects SAF2009-14724-C02-02
Ministerio de España de Economía y Competitividad y el Fondo Europeo de Desarrollo Regional, (projects SAF2012-40227-C02-02 e IPT-2012-0438-010000)
Ministerio de España de Economía y Competitividad y el Fondo Europeo de Desarrollo Regional, (projects SAF2012-40227-C02-02 e IPT-2012-0438-010000)
Version del Editor
Propietario de los Derechos
© 2014 The Author(s)
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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Ficheros en el ítem
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