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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/59087

    Título
    Immune system disorders, cancer and viral infections: A new treatment opportunity for the immune checkpoint inhibitors
    Autor
    Olivares Hernández, Alejandro
    Figuero Pérez, Luis
    MiRamóntes González, José PabloAutoridad UVA Orcid
    López Gutiérrez, Álvaro
    González Sarmiento, Rogelio
    Cruz Hernández, Juan Jesús
    Fonseca Sánchez, Emilio
    Año del Documento
    2021
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Life, 2021, vol. 11, n. 12, 1400
    Resumen
    The relationship between viral infections and cancer is well known and has been established for decades. Multiple tumours are generated from alterations secondary to viral infections 2 resulting from a dysregulation of the immune system in many cases. Certain causal relationships, such as that between the Epstein–Barr virus (EBV) in nasopharyngeal cancer or hepatitis C and B viruses in hepatocarcinoma, have been clearly established, and their implications for the prognosis and treatment of solid tumours are currently unknown. Multiple studies have evaluated the role that these infections may have in the treatment of solid tumours using immunotherapy. A possible relationship between viral infections and an increased response to immune checkpoint inhibitors (ICIs) has been established at a theoretical level in solid neoplasms, such as EBV-positive cavum cancer and human papillomavirus (HPV)-positive and oropharyngeal cancer. These could yield a greater response associated with the activation of the immune system secondary to viral infection, the consequence of which is an increase in survival in these patients. That is why the objective of this review is to assess the different studies or clinical trials carried out in patients with solid tumours secondary to viral infections and their relationship to the response to ICIs.
    Materias (normalizadas)
    Medicina
    Medicina Interna
    Cancer Research
    Materias Unesco
    3205 Medicina Interna
    Palabras Clave
    Viral infections
    Immunotherapy
    Immune checkpoint inhibitors
    Solid tumours
    Infecciones virales
    Inmunoterapia
    Inhibidores de puntos de control inmunitarios
    Tumores sólidos
    Revisión por pares
    SI
    DOI
    10.3390/life11121400
    Version del Editor
    https://www.mdpi.com/2075-1729/11/12/1400
    Propietario de los Derechos
    © 2021 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/59087
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP52 - Artículos de revista [181]
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    Immune-System-Disorders-Cancer-and-Viral-Infections.pdf
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    Atribución 4.0 InternacionalLa licencia del ítem se describe como Atribución 4.0 Internacional

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