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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/59238

    Título
    Goals and challenges of stem cell-based therapy for corneal blindness due to limbal deficiency
    Autor
    Calonge, MargaritaAutoridad UVA Orcid
    Nieto Miguel, TeresaAutoridad UVA Orcid
    De La Mata Sampedro, AnaAutoridad UVA Orcid
    Galindo de la Rosa, SaraAutoridad UVA Orcid
    Herreras Cantalapiedra, José MaríaAutoridad UVA Orcid
    López Paniagua, MarinaAutoridad UVA Orcid
    Año del Documento
    2021
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Pharmaceutics, 2021, vol. 13, n. 9, 1483
    Abstract
    Corneal failure is a highly prevalent cause of blindness. One special cause of corneal failure occurs due to malfunction or destruction of the limbal stem cell niche, upon which the superficial cornea depends for homeostatic maintenance and wound healing. Failure of the limbal niche is referred to as limbal stem cell deficiency. As the corneal epithelial stem cell niche is easily accessible, limbal stem cell-based therapy and regenerative medicine applied to the ocular surface are among the most highly advanced forms of this novel approach to disease therapy. However, the challenges are still great, including the development of cell-based products and understanding how they work in the patient’s eye. Advances are being made at the molecular, cellular, and tissue levels to alter disease processes and to reduce or eliminate blindness. Efforts must be coordinated from the most basic research to the most clinically oriented projects so that cell-based therapies can become an integrated part of the therapeutic armamentarium to fight corneal blindness. We undoubtedly are progressing along the right path because cell-based therapy for eye diseases is one of the most successful examples of global regenerative medicine.
    Materias (normalizadas)
    Medicina regenerativa
    Ophthalmology
    Células madre
    Materias Unesco
    3201.09 Oftalmología
    Palabras Clave
    Blindness
    Cell therapy
    Limbal niche
    Ceguera
    Terapia celular
    Nicho limbal
    Revisión por pares
    SI
    DOI
    10.3390/pharmaceutics13091483
    Patrocinador
    Junta de Castilla y León (VA268P18)
    Ministerio de Ciencia e Innovación (PID2019-105525RB-100)
    Instituto de Salud Carlos III (CB06/01/003)
    Version del Editor
    https://www.mdpi.com/1999-4923/13/9/1483
    Propietario de los Derechos
    © 2021 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/59238
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • IOBA - Artículos de revista [82]
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    Universidad de Valladolid

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