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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/59533

    Título
    Metronomic anti-cancer therapy: A multimodal therapy governed by the tumor microenvironment
    Autor
    Muñoz Martínez, RaquelAutoridad UVA Orcid
    Girotti ., AlessandraAutoridad UVA Orcid
    Hileeto, Denise
    Arias Vallejo, Francisco JavierAutoridad UVA Orcid
    Año del Documento
    2021
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Cancers, 2021, vol. 13, n. 21, 5414
    Résumé
    The concept of cancer as a systemic disease, and the therapeutic implications of this, has gained special relevance. This concept encompasses the interactions between tumor and stromal cells and their microenvironment in the complex setting of primary tumors and metastases. These factors determine cellular co-evolution in time and space, contribute to tumor progression, and could counteract therapeutic effects. Additionally, cancer therapies can induce cellular and molecular responses in the tumor and host that allow them to escape therapy and promote tumor progression. In this study, we describe the vascular network, tumor-infiltrated immune cells, and cancer-associated fibroblasts as sources of heterogeneity and plasticity in the tumor microenvironment, and their influence on cancer progression. We also discuss tumor and host responses to the chemotherapy regimen, at the maximum tolerated dose, mainly targeting cancer cells, and a multimodal metronomic chemotherapy approach targeting both cancer cells and their microenvironment. In a combination therapy context, metronomic chemotherapy exhibits antimetastatic efficacy with low toxicity but is not exempt from resistance mechanisms. As such, a better understanding of the interactions between the components of the tumor microenvironment could improve the selection of drug combinations and schedules, as well as the use of nano-therapeutic agents against certain malignancies.
    Materias (normalizadas)
    Medicina
    Oncología
    Cancer Research
    Materias Unesco
    3207.13 Oncología
    Palabras Clave
    Metronomic chemotherapy
    Tumor microenvironment
    Nanomedicine
    Quimioterapia metronómica
    Microentorno tumoral
    Nanomedicina
    Revisión por pares
    SI
    DOI
    10.3390/cancers13215414
    Patrocinador
    Ministerio de Ciencia e Innovación y Ministerio de Universidades - CIBER-BBN e ISCIII (DTS19/00162 y PID2019-106386RB-I00)
    Version del Editor
    https://www.mdpi.com/2072-6694/13/21/5414
    Propietario de los Derechos
    © 2021 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/59533
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    • BIOFORGE - Artículos de revista [89]
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    Metronomic-Anti-Cancer-Therapy.pdf
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    Atribución 4.0 InternacionalExcepté là où spécifié autrement, la license de ce document est décrite en tant que Atribución 4.0 Internacional

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