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dc.contributor.authorČižman, Milan
dc.contributor.authorMioč, Verica
dc.contributor.authorBajec, Tom
dc.contributor.authorParagi, Metka
dc.contributor.authorKastrin, Tamara
dc.contributor.authorCarita Gonçalves, José Manuel
dc.date.accessioned2023-05-09T12:49:00Z
dc.date.available2023-05-09T12:49:00Z
dc.date.issued2021
dc.identifier.citationAntibiotics, 2021, vol. 10, n.7, 758es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/59552
dc.descriptionProducción Científicaes
dc.description.abstractThere is a lack of long-term studies that correlate different metrics of antibiotic consumption and resistance of invasive S. pneumoniae. The present study aims to investigate the correlation between national outpatients total antibiotic, penicillin and broad spectrum penicillins consumption expressed in daily doses per 1000 inhabitants per day (DID) with the ATC/DDDs, WHO version of 2019 (new version) and 2018 (old version), number of prescriptions per 1000 inhabitants per year (RxIDs) and number of packages per 1000 inhabitant per day (PIDs) with the resistance of invasive S. pneumoniae in Slovenia in the period from 2000 to 2018. The prevalence of penicillin resistance of invasive S. pneumoniae decreased by 47.13%, from 19.1% to 10.1%. Decline of resistance showed the highest correlation (R = 0.86) between RxIDs followed by PID (R = 0.85) and resistance of S. pneumoniae. Higher correlation between total use of antibiotics expressed in DID WHO version 2019 (R = 0.80) than for WHO version 2018 (R = 0.78) was found. Very high (R = 0.84) correlation between use of β-lactams expressed in PID, and RxIDs (R = 0.82) and reasonable (R = 0.59) correlation expressed in DIDs version 2019 was shown as well. The consumption of broad -spectrum penicillins (J01CA and J01CR02) expressed in PID (R = 0.72) and RxIDs (0.57) correlated significantly with the resistance of S. pneumoniae as well. A new finding of this study is that RxIDs correlated better with the resistance of S. pneumoniae than total consumption of antibiotics expressed in DID and significant correlations exist between use of broad-spectrum penicillins expressed in PID and RxIDs.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBacteriases
dc.subjectAntibióticoses
dc.subjectInfectious Diseaseses
dc.subject.classificationS. pneumoniaees
dc.subject.classificationResistancees
dc.subject.classificationAntibiotices
dc.subject.classificationPrescription ratees
dc.subject.classificationResistenciaes
dc.subject.classificationAntibióticoes
dc.subject.classificationTasa de prescripciónes
dc.titleCorrelation between antibiotic consumption and resistance of invasive streptococcus pneumoniaees
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2021 The Authorses
dc.identifier.doi10.3390/antibiotics10070758es
dc.relation.publisherversionhttps://www.mdpi.com/2079-6382/10/7/758es
dc.identifier.publicationfirstpage758es
dc.identifier.publicationissue7es
dc.identifier.publicationtitleAntibioticses
dc.identifier.publicationvolume10es
dc.peerreviewedSIes
dc.identifier.essn2079-6382es
dc.rightsAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones
dc.subject.unesco2414.01 Antibióticoses
dc.subject.unesco2414.04 Bacteriologíaes


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