• español
  • English
  • français
  • Deutsch
  • português (Brasil)
  • italiano
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Navegar

    Todo o repositórioComunidadesPor data do documentoAutoresAssuntosTítulos

    Minha conta

    Entrar

    Estatística

    Ver as estatísticas de uso

    Compartir

    Ver item 
    •   Página inicial
    • PRODUÇÃO CIENTÍFICA
    • Departamentos
    • Dpto. Biología Celular, Histología y Farmacología
    • DEP05 - Artículos de revista
    • Ver item
    •   Página inicial
    • PRODUÇÃO CIENTÍFICA
    • Departamentos
    • Dpto. Biología Celular, Histología y Farmacología
    • DEP05 - Artículos de revista
    • Ver item
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano

    Exportar

    RISMendeleyRefworksZotero
    • edm
    • marc
    • xoai
    • qdc
    • ore
    • ese
    • dim
    • uketd_dc
    • oai_dc
    • etdms
    • rdf
    • mods
    • mets
    • didl
    • premis

    Citas

    Academic Search

    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/5984

    Título
    Modulation of Ca2+ release and Ca2+ oscillations in HeLa cells and fibroblasts by mitochondrial Ca2+ uniporter stimulation
    Autor
    Vay, Laura
    Hernández San Miguel, Esther
    Santo Domingo, Jaime
    Domínguez Lobatón, María Carmenuntranslated ORCID
    Moreno Díaz-Calderón, Alfredountranslated ORCID
    Montero Zoccola, María Teresauntranslated ORCID
    Álvarez Martín, Javieruntranslated ORCID
    Año del Documento
    2007
    Editorial
    Wiley
    Descripción
    Producción Científica
    Documento Fuente
    Journal of Physiology, 2007, vol. 580, n. 1, p. 39-49
    Resumo
    The recent availability of activators of the mitochondrial Ca2+ uniporter allows direct testing of the influence of mitochondrial Ca2+ uptake on the overall Ca2+ homeostasis of the cell. We show here that activation of mitochondrial Ca2+ uptake by 4,4 ,4 -(4- propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT) or kaempferol stimulates histamine-induced Ca2+ release from the endoplasmic reticulum (ER) and that this effect is enhanced if the mitochondrial Na+–Ca2+ exchanger is simultaneously inhibited with CGP37157. This suggests that both Ca2+ uptake and release from mitochondria control the ability of local Ca2+ microdomains to produce feedback inhibition of inositol 1,4,5-trisphosphate receptors (InsP3Rs). In addition, the abilityof mitochondria tocontrolCa2+ release fromtheERallowsthemtomodulate cytosolic Ca2+ oscillations. In histamine stimulatedHeLa cells and human fibroblasts, both PPT and kaempferol initially stimulated and later inhibited oscillations, although kaempferol usually induced a more prolonged period of stimulation. Both compounds were also able to induce the generation of Ca2+ oscillations in previously silent fibroblasts. Our data suggest that cytosolic Ca2+ oscillations are exquisitely sensitive to the rates of mitochondrial Ca2+ uptake and release, which precisely control the size of the local Ca2+ microdomains around InsP3Rs and thus the ability to produce feedback activation or inhibition of Ca2+ release.
    Materias (normalizadas)
    Calcio en el organismo
    ISSN
    0022-3751
    Revisión por pares
    SI
    DOI
    10.1113/jphysiol.2006.126391
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/5984
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP05 - Artículos de revista [110]
    Mostrar registro completo
    Arquivos deste item
    Nombre:
    ALVAREZ 21- Modulation of Ca2+ release.pdf
    Tamaño:
    987.7Kb
    Formato:
    Adobe PDF
    Descripción:
    PD-112
    Thumbnail
    Visualizar/Abrir
    Attribution-NonCommercial-NoDerivatives 4.0 InternationalExceto quando indicado o contrário, a licença deste item é descrito como Attribution-NonCommercial-NoDerivatives 4.0 International

    Comentarios

    Universidad de Valladolid

    Powered by MIT's. DSpace software, Version 5.10