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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/59922

    Título
    Marine heterocyclic compounds that modulate intracellular calcium signals: Chemistry and synthesis approaches
    Autor
    González Andrés, PaulaAutoridad UVA Orcid
    Fernández Peña, LauraAutoridad UVA Orcid
    Díez Poza, CarlosAutoridad UVA Orcid
    Villalobos Jorge, Carlos
    Núñez Llorente, LucíaAutoridad UVA
    Barbero Pérez, María AsunciónAutoridad UVA Orcid
    Año del Documento
    2021
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Marine Drugs, 2021, Vol. 19, Nº. 2, 78
    Resumo
    Intracellular Ca2+ plays a pivotal role in the control of a large series of cell functions in all types of cells, from neurotransmitter release and muscle contraction to gene expression, cell proliferation and cell death. Ca2+ is transported through specific channels and transporters in the plasma membrane and subcellular organelles such as the endoplasmic reticulum and mitochondria. Therefore, dysregulation of intracellular Ca2+ homeostasis may lead to cell dysfunction and disease. Accordingly, chemical compounds from natural origin and/or synthesis targeting directly or indirectly these channels and proteins may be of interest for the treatment of cell dysfunction and disease. In this review, we show an overview of a group of marine drugs that, from the structural point of view, contain one or various heterocyclic units in their core structure, and from the biological side, they have a direct influence on the transport of calcium in the cell. The marine compounds covered in this review are divided into three groups, which correspond with their direct biological activity, such as compounds with a direct influence in the calcium channel, compounds with a direct effect on the cytoskeleton and drugs with an effect on cancer cell proliferation. For each target, we describe its bioactive properties and synthetic approaches. The wide variety of chemical structures compiled in this review and their significant medical properties may attract the attention of many different researchers.
    Materias (normalizadas)
    Organic chemistry
    Drugs
    Drogas
    Heterocyclic compounds
    Compuestos heterocíclicos
    Pharmacology/Toxicology
    Calcio en el organismo
    Calcio, Conductos de
    Organic compounds - Synthesis
    Compuestos orgánicos - Síntesis
    Clinical chemistry
    Drug development
    Medicamentos - Investigación
    Materias Unesco
    3209 Farmacología
    3214 Toxicología
    Palabras Clave
    Marine drugs
    Drogas marinas
    ISSN
    1660-3397
    Revisión por pares
    SI
    DOI
    10.3390/md19020078
    Patrocinador
    Ministerio de Ciencia e Innovación - (grant RTI2018-099298-B-100)
    Junta de Castilla y León - (grant VA294-P18)
    Version del Editor
    https://www.mdpi.com/1660-3397/19/2/78
    Propietario de los Derechos
    © 2021 The authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/59922
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP67 - Artículos de revista [53]
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    Marine-Heterocyclic-Compounds.pdf
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    Universidad de Valladolid

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