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Effects of Withania somnifera (Ashwagandha) on hematological and biochemical markers, hormonal behavior, and oxidant response in healthy adults: A systematic review
Año del Documento
Current Nutrition Reports, 2023.
Purpose of Review Withania somnifera (L.) Dunal (Ws) is a common herb plant that has been used for centuries to treat a wide range of conditions, particularly certain chronic diseases due to its antidiabetic, cardioprotective, antistress, and chondroprotec- tive effects, among many others. No conclusive evidence, however, exists about the potential health effects of Ws in adults with- out chronic conditions. We aimed to evaluate the current evidence on the health benefits of Ws supplementation in healthy adults. Recent Findings Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically reviewed studies indexed in Web of Science, Scopus, and PubMed to assess the effects of Ws on hema- tological and biochemical markers, hormonal behavior, and oxidant response in healthy adults. Original articles published up to March 5, 2022, with a controlled trial design or pre-post intervention design, in which supplementation of Ws was compared to a control group or data prior to intervention were included. Among 2,421 records identified in the search, 10 studies met the inclusion criteria. Overall, most of the studies reported beneficial effects of the Ws supplementation, and no serious adverse events were reported. Participants supplemented with Ws displayed reduced levels of oxidative stress and inflammation, and counterbalanced hormone levels. No evidence of the beneficial effects of Ws supplementation on hematological markers was reported. Summary Ws supplementation appears to be safe, may regulate hormone levels, and has potent anti-inflammatory and anti- oxidant effects. However, further studies are needed to elucidate the relevance of its application.
Revisión por pares
Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCLE
Version del Editor
Propietario de los Derechos
© 2023 The Author(s)
Tipo de versión
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional