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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/64964

    Título
    Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study
    Autor
    Domingo Relloso, Arce
    Grau Pérez, María
    Galán Chilet, Inmaculada
    Garrido Martínez, María J.
    Tormos, Carmen
    Navas Acién, Ana
    Gómez Ariza, José L.
    Monzo Beltrán, Lidia
    Saez Tormo, Guillermo
    García Barrera, Tamara
    Dueñas Laita, AntonioAutoridad UVA
    Briongos Figuero, Laisa SocorroAutoridad UVA Orcid
    Chaves, Felipe Javier
    Redón Mas, Josep
    Téllez Plaza, Maria
    Martín Escudero, Juan CarlosAutoridad UVA
    Año del Documento
    2019
    Editorial
    Pergamon-Elsevier Science LTD, USA
    Documento Fuente
    Environment International, febrero 2019, 123, 171-80
    Résumé
    Introduction: Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population. Objectives: We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8‑oxo‑7,8‑dihydroguanine (8-oxo-dG), in a representative sample of a general population from Spain (Hortega Study). Methods: Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants. Results: The geometric mean ratios (GMRs) of GSSG/GSH comparing the 80th to the 20th percentiles of metal distributions were 1.15 (95% confidence intervals [95% CI]: 1.03–1.27) for Mo, 1.17 (1.05–1.31) for Ba, 1.23 (1.04–1.46) for Cr and 1.18 (1.00–1.40) for V. For MDA, the corresponding GMRs (95% CI) were 1.13 (1.03–1.24) for Zn and 1.12 (1.02–1.23) for Cd. In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12 (1.01–1.23) for Zn and 1.09 (0.99–1.20) for Cd. Cr for GSSG/GSH and Zn for MDA and 8-oxo-dG drove most of the observed associations. Principal component (PC) 1 (largely reflecting non-essential metals) was positively associated with GSSG/GSH. The association of PC2 (largely reflecting essential metals) was positive for GSSG/ GSH but inverse for MDA. Conclusions: Urine Ba, Cd, Cr, Mo, V and Zn were positively associated with oxidative stress measures at metal exposure levels relevant for the general population. The potential health consequences of environmental, including nutritional, exposure to these metals warrants further investigation.
    Materias (normalizadas)
    Urine metals, Oxidative stress, Metal mixtures, Population-based
    ISSN
    0160-4120
    Revisión por pares
    SI
    DOI
    10.1016/j.envint.2018.11.055
    Patrocinador
    Research in Health Sciences [CP12/03080, PI10/0082, PI13/01848, PI07/0497 and PI11/00726]; GRUPOS 03/101, PROMETEO/2009/029 and 2005/027, AMP07/075 and ACOMP/2013/039 from the Valencia Government; GRS/279/A/08 from Castilla-Leon Government; European Network of Excellence Ingenious Hypercare (EPSS-037093) from the European Commission; Retics (PREDIMED RD06/0045/0006); CIBER Fisiopatología Obesidad y Nutrición (CIBERobn) [CIBER-02-08-2009, CB06/03 and CB12/03/30016] and CIBER de Diabetes y Enfermedades Metabólicas Relacionadas (CIBERDEM CB07/0/018). The Strategic Action for Research in Health sciences, Retics, CIBEROBN and CIBERDEM are initiatives from Carlos III Health Institute Madrid and the Spanish Ministry of Economy and Competitiveness and co-funded with European Funds for Regional Development (FEDER).
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/64964
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    2019 EnvironInter Urinary metals.pdf
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