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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/65357

    Título
    Elastin-like recombinamer-based devices releasing Kv1.3 blockers for the prevention of intimal hyperplasia: An in vitro and in vivo study
    Autor
    Moreno Estar, SaraAutoridad UVA Orcid
    Serrano, Sofía
    Arévalo Martínez, MarycarmenAutoridad UVA
    Cidad Velasco, María Del PilarAutoridad UVA Orcid
    López López, José RamónAutoridad UVA Orcid
    Santos García, María MercedesAutoridad UVA Orcid
    Pérez García, María TeresaAutoridad UVA Orcid
    Arias Vallejo, Francisco JavierAutoridad UVA Orcid
    Año del Documento
    2020
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Acta Biomaterialia, octubre 2020, vol. 115, p. 264-274.
    Resumen
    Coronary artery disease (CAD) is the most common cardiovascular disorder. Vascular surgery strategies for coronary revascularization (either percutaneous or open) show a high rate of failure because of restenosis of the vessel, due to phenotypic switch of vascular smooth muscle cells (VSMCs) leading to proliferation and migration. We have previously reported that the inhibition of Kv1.3 channel function with selective blockers represents an effective strategy for the prevention of restenosis in human vessels used for coronary angioplasty procedures. However, delivery systems for controlled release of these drugs have not been investigated. Here we tested the efficacy of several formulations of elastin like recombinamers (ELRs) hydrogels to deliver the Kv1.3 blocker PAP-1 in various restenosis models. The dose and time course of PAP-1 release from ELRs click hydrogels was able to inhibit human VSMC proliferation in vitro as well as remodeling of human vessels in organ culture and restenosis in in vivo models. We conclude that this combination of active compound and advanced delivery method could improve the outcomes of vascular surgery in patients. STATEMENT OF SIGNIFICANCE: Vascular surgery strategies for coronary revascularization show a high rate of failure, because of occlusion (restenosis) of the vessel, due to vascular smooth muscle cells proliferation and migration. We have previously reported that blockers of Kv1.3 channels represent an effective anti-restenosis therapy, but delivery systems for their controlled release have not being explored. Here we tested the efficacy of several formulations of elastin like recombinamers (ELRs) hydrogels to deliver the Kv1.3 blocker PAP-1 in various restenosis models, both in vivo and in vitro, and also in human vessels. We demonstrated that combination of active compound and advanced delivery method could improve the outcomes of vascular surgery in patients.
    Materias Unesco
    23 Química
    32 Ciencias Médicas
    Palabras Clave
    Vascular smooth muscle cells
    Intimal hyperplasia
    Elastin-like recombinamers
    Hydrogels
    Kv1.3 channels
    Local drug delivery
    ISSN
    1742-7061
    Revisión por pares
    SI
    DOI
    10.1016/j.actbio.2020.07.053
    Patrocinador
    Unión Europea-Horizonte 2020 (EU H2020-NMP-2014-646075)
    Ministerio de Economía y Competitividad (BFU2016-75360-R, DTS19/00162, MAT2016-79435-R, MAT2016-78903-R, RTI2018-096320-B-C22)
    Junta de Castilla y León (VA114P17, VA317P18)
    Centro en Red de Medicina regenerativa y Terapia celular de Castilla y León
    Version del Editor
    https://www.sciencedirect.com/science/article/pii/S1742706120304505
    Propietario de los Derechos
    © 2020 Acta Materialia Inc
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/65357
    Tipo de versión
    info:eu-repo/semantics/acceptedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • BIOFORGE - Artículos de revista [89]
    • VASCUMIT - Artículos de revista [47]
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    BIOMAT-S-20-02458.pdf
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    Universidad de Valladolid

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