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    • PRODUZIONE SCIENTIFICA
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    • Dpto. Pediatría e Inmunología, Obstetricia y Ginecología, Nutrición y Bromatología, Psiquiatría e Historia de la Ciencia
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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/66450

    Título
    Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia
    Autor
    Díez Revuelta, ÁlvaroAutoridad UVA
    Cieza-Borrella, Clara
    Suazo, Vanessa
    González Sarmiento, Rogelio
    Papiol, Sergi
    Molina Rodríguez, VicenteAutoridad UVA Orcid
    Año del Documento
    2014
    Documento Fuente
    Annals of General Psychiatry 13(18):1-8
    Abstract
    Background Neuregulins are a family of signalling proteins that orchestrate a broad range of cellular responses. Four genes encoding Neuregulins 1–4 have been identified so far in vertebrates. Among them, Neuregulin 1 and Neuregulin 3 have been reported to contribute to an increased risk for developing schizophrenia. We hypothesized that three specific variants of these genes (rs6994992 and rs3924999 for Neuregulin 1 and rs10748842 for Neuregulin 3) that have been related to this illness may modify information processing capacity in the cortex, which would be reflected in electrophysiological parameters (P3b amplitude or gamma noise power) and/or cognitive performance. Methods We obtained DNA from 31 patients with schizophrenia and 23 healthy controls and analyzed NRG1 rs6994992, NRG1 rs3924999 and NRG3 rs10748842 promoter polymorphisms by allelic discrimination with real-time polymerase chain reaction (PCR). We compared cognitive outcome, P300 amplitude parameters and an electroencephalographic measure of noise power in the gamma band between the groups dichotomized according to genotype. Results Contrary to our hypothesis, we could not detect any significant influence of variation in Neuregulin 1/Neuregulin 3 polymorphisms on cognitive performance or electrophysiological parameters of patients with schizophrenia. Conclusions Despite our findings, we cannot discard that other genetic variants and, more likely, interactions between those variants and with genetic variation related to different pathways may still influence cerebral processing in schizophrenia.
    Revisión por pares
    SI
    DOI
    10.1186/1744-859X-13-18
    Idioma
    spa
    URI
    https://uvadoc.uva.es/handle/10324/66450
    Tipo de versión
    info:eu-repo/semantics/draft
    Derechos
    openAccess
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    • DEP55 - Artículos de revista [208]
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