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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/6845

    Título
    Localization and Function of Cat Carotid Body Nicotinic Receptors
    Autor
    Dinger, Bruce
    González Martínez, Constancio
    Yoshizaki, Katsuaki
    Fidone, Salvatore
    Año del Documento
    1985
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Brain Research, 1985, vol. 339, p. 295-304
    Abstract
    Acetylcholine and nicotinic agents excite cat carotid body chemoreceptors and modify their response to natural stimuli. The present experiments utilized [125I]a-bungarotoxin ([125I]a-BGT) to localize within the chemosensory tissue the possible sites of action of exogenous and endogenous nicotinic cholinergic substances. In vitro equilibrium binding studies of intact carotid bodies determined a K d of 5.57 nM and a Bma x of 9.21 pmol/g of tissue. Chronic section (12-15 days) of the carotid sinus nerve (CSN) did not change the amount of displaceable toxin binding. In contrast, the specific binding was reduced by 46% following removal of the superior cervical ganglion. Light microscope autoradiography of normal, CSN-denervated and sympathectomized carotid bodies revealed displaceable binding sites concentrated in lobules of type I and type II cells. Treatment of carotid bodies with 50 nM a-BGT in vitro reduced by 50% the release of [3H]dopamine (synthesized from [3H]tyrosine) caused by hypoxia or nicotine, and also significantly reduced the stimulus-. evoked discharges recorded from the CSN. The data suggest (1) an absence of ct-BGT binding sites on the afferent terminals of the CSN and (2) that nicotinic receptors located within parenchymal cell lobules may modulate the release of catecholamines from these cells.
    Materias (normalizadas)
    Neurofisiología
    ISSN
    0006-8993
    Revisión por pares
    SI
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/6845
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP06 - Artículos de revista [353]
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalLa licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 International

    Universidad de Valladolid

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